Tracking nanoparticles: from cell culture to in vivo delivery

追踪纳米颗粒：从细胞培养到体内递送

• 批准号: FL210100107
• 负责人: Prof Robert Parton
• 金额: $ 207.08万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Australian Laureate Fellowships
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-12-01 至 2027-12-01
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FL210100107
• 关键词: Tracking; nanoparticles; cell; culture; vivo

Understanding how cells function in the ‘real-time’ context of a living organism is a key challenge in the new era of cell biology. Using super-resolution light microscopy and state-of-the-art correlative electron microscopy together with model systems, this Fellowship aims to deliver new understandings of cells in their natural environment. Significantly, the project will elucidate how proteins or nanoparticles pass from the bloodstream into tissues and then into cells, and in doing so deliver much-needed knowledge of protein and particle trafficking in situ. Outcomes and benefits include leading-edge fundamental science into the function of cells, education, outreach and building of Australian capacity in high-demand skill sets.

了解细胞如何在生物体的“实时”环境中发挥作用是细胞生物学新时代的一个关键挑战。利用超分辨率光学显微镜和最先进的相关电子显微镜以及模型系统，该奖学金旨在提供对自然环境中细胞的新理解。重要的是，该项目将阐明蛋白质或纳米颗粒如何从血液进入组织，然后进入细胞，并在此过程中提供蛋白质和颗粒原位运输的急需知识。成果和收益包括将前沿基础科学纳入细胞功能，教育，推广和建设澳大利亚高需求技能的能力。