NON-INVASIVE GLUCOSE MONITORING USING EXHALED BREATH CONDENSATE

使用呼出气体冷凝液进行无创血糖监测

• 批准号: 7952116
• 负责人: RICHARD E PRATLEY
• 金额: $ 1.03万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7952116
• 关键词: Air; Blood; Blood Glucose; Blood capillaries; Breathing; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Development; Diabetes Mellitus; Exhalation; Fingers; Funding; Glucose; Grant; Infection; Institution; Lead; Liquid substance; Measurement; Measures; Methods; OGTT; Patients; Phase; Physiological; Plasma; Research; Research Personnel; Resources; Risk; Skin; Source; Techniques; Testing; Time; United States National Institutes of Health; base; capillary; glucose monitor; information gathering; non-diabetic; response; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Patients with diabetes benefit from self glucose monitoring. Current techniques for performing self glucose monitoring require piercing the skin with a lancet to obtain a droplet of blood. Because of this, they are associated with some discomfort and a small risk of infection. This study tests whether it is possible to monitor glucose non-invasively by measuring glucose levels in fluid that is collected from the air that is expired during normal breathing (this fluid is called the exhaled breath condensate or EBC). This proof of concept study will proceed in two phases. The first phase will attempt to demonstrate that glucose can be measured in EBC and that it is correlated with blood glucose measurements. EBC will be collected using a standard non-invasive apparatus in volunteers with diabetes and non-diabetic controls. EBC glucose will be compared to capillary blood glucose measurements (finger stick method) and plasma glucose measurements. If this phase successfully demonstrates that glucose can be measured in EBC and that it reflects capillary and plasma glucose levels, then the second phase of testing will be performed. In the second phase, the response of EBC glucose to physiological changes in plasma glucose will be assessed. EBC will be collected before and during a standard 75-gram oral glucose tolerance test in patients with diabetes and non-diabetic controls. The time course of changes in EBC glucose will be compared to those of capillary and plasma glucose levels. The information gathered from this study will provide information that may lead to the development of a non-invasive glucose monitor, based on the principle of EBC glucose measurements, for patients with diabetes.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 糖尿病患者受益于自我血糖监测。目前进行自我血糖监测的技术需要用柳叶刀刺穿皮肤以获得一滴血。正因为如此，它们与一些不适和感染的小风险有关。这项研究测试是否有可能通过测量从正常呼吸过程中呼出的空气中收集的液体(这种液体被称为呼出的呼吸冷凝液或EBC)中的葡萄糖水平来非侵入性地监测血糖。 这项概念验证研究将分两个阶段进行。第一阶段将试图证明，葡萄糖可以在EBC中测量，并且它与血糖测量相关。糖尿病志愿者和非糖尿病志愿者将使用标准的非侵入性仪器采集EBC。EBC血糖将与毛细血管血糖测量(指棒法)和血糖测量进行比较。如果这一阶段成功地证明了可以用EBC测量葡萄糖，并且它反映了毛细血管和血糖水平，那么将进行第二阶段的测试。在第二阶段，我们将评估EBC葡萄糖对血糖生理性变化的反应。糖尿病患者和非糖尿病对照组患者在标准的75克口服葡萄糖耐量试验之前和期间收集EBC。EBC血糖变化的时间进程将与毛细血管和血糖水平进行比较。 这项研究收集的信息将为糖尿病患者开发基于EBC血糖测量原理的非侵入性血糖监测仪提供信息。