Improving the Bryan Vivarium in Support of the Rodent Imaging Core

描述(由申请者提供)：杜克大学的动物设施支持公共卫生服务(PHS)和非PHS来源资助的动物相关研究和教学。NCRR作为国家生物医学技术资源中心，支持杜克大学活体显微镜中心(CIVM)与动物研究相关的成像工作。CIVM是NCRR资助的最大的影像资源，也是NCI的小动物影像资源计划。CIVM包括MRI、Micro-CT/Micro X光、超声波、成像生物支持、超极化气体偏振器、计算机/网络/可视化工具、线圈光刻/蚀刻和高纵横比指圈T-tech磨床。数据库为世界各地的机构提供基于动物的成像信息。2008年3月，CIVM参加了44个内部和外部的项目，CIVM的年度小动物成像研讨会每节吸引了100多名参与者。 CIVM在布莱恩研究大楼的一楼，CIVM动物在地下室的动物设施里。目前，由于机构检疫政策，该中心对来自不同机构的动物进行纵向研究的能力有限。此外，缺乏消毒能力限制了免疫缺陷啮齿动物或生物危险材料的使用。设施现代化将使CIVM能够扩展能力。 其应用目标是：1)更换陈旧的笼式垫圈，增加一个高压灭菌器，以支持更多种类的啮齿动物住房；2)增加一个生物安全柜子，为外科手术和危险物质提供保护区；3)通过移除隔离隔间提供更多的住房功能；重新布置所有楼层；4)提供通风的机架和动物转运站，以减少疾病传播的可能性；5)扩大自动浇水，以提高操作效率；6)建立干净-肮脏的走廊系统，以保持动物的健康状况。

DESCRIPTION (provided by applicant): Duke's animal facilities support animal-related research and teaching funded by Public Health Service (PHS) and non-PHS sources. NCRR supports Duke's Center for In Vivo Microscopy's (CIVM) imaging efforts related to animal research as a National Biomedical Technology Resource Center. CIVM is NCRR's largest funded imaging resource, and is a NCI Small Animal Imaging Resource Program. The CIVM includes MRI, micro-CT/micro x-ray, ultrasound, imaging biological support, hyperpolarized gases polarizer, computers/network/visualization tools, coil lithography/etching, and high-aspect finger coils T-tech mill. Databases provide animal-based imaging information to institutions world-wide. March 2008 showed CIVM in forty-four projects both internal and external, and CIVM's annual Small Animal Imaging Workshop attracts 100+ participants per session. CIVM is on the first floor of the Bryan Research Building, CIVM animals are in the basement animal facility. Currently, the Center has limited ability to perform longitudinal studies with animals from various institutions due to institutional quarantine policies. Also, lack of sterilization capabilities limits CIVM use of immunodeficient rodents or bio-hazardous materials. Facility modernization will allow CIVM to expand capabilities. The application objectives are: 1) Replace the antiquated cage washer and add an autoclave to support wider varieties of rodent housing; 2) add a bio-safety cabinet, providing protected areas for surgical procedures and hazardous agents; 3) Provide more housing capabilities by removing isolation cubicles; re-do all floors; 4) Provide ventilated racks and animal transfer stations to lessen disease transmission possibilities; 5) extend automatic watering for more efficient operation; 6) establish a clean-dirty corridor system to maintain animal health status.