LATE MAXILLARY PROTRACTION FOR CLEFT LIP AND PALATE

描述（由申请人提供）：该计划拨款将用于计划在五个研究中心进行随机对照试验，以测试青少年上颌前牵引是否可以作为正颌手术的非手术替代方案，作为唇腭裂患者人群中骨骼反牙合的治疗方法。我们将比较唇腭裂患者上颌前牵引治疗在12-14岁与唇腭裂患者谁接受正颌手术在较晚的年龄，通常是17-19岁，当颌骨生长确定的放射学和临床评估，已经停止。进入上颌前牵引方案的患者将比手术患者更早接受治疗。这项计划补助金将测试随机试验的可行性，并为长期研究提供基础，该研究将跟踪长期患者到他们的青少年后期，当他们传统上接受手术治疗时，以研究青春期晚期生长和治疗复发对上颌前牵引的影响。项目叙述：本研究旨在为唇腭裂儿童的外科和正畸护理提供一个可靠的证据基础，唇腭裂是最常见的面部先天缺陷。这笔赠款将用于计划在五个研究中心进行临床试验，以测试整形外科非手术治疗是否可以替代这些患者的手术。

DESCRIPTION (provided by applicant): This planning grant will serve to plan a randomized control trial among five research centers to test whether adolescent maxillary protraction can be a non-surgical alternative to orthognathic surgery as a treatment for a skeletal underbite in the cleft lip and palate patient population. We will compare cleft lip and palate patients treated with maxillary protraction at ages 12-14 with cleft lip and palate patients who undergo orthognathic surgery at a later age, usually ages 17-19, when jaw growth as determined by radiographic and clinical assessment, has ceased. The patients who enter the maxillary protraction protocol will be treated earlier than the surgery patients. This planning grant will test the feasibility of a randomized trial and provide the basis for a long-term study which would follow the protracted patients through their late teenage years when they would traditionally be treated with surgery in order to study the effects of late growth and treatment relapse on maxillary protraction during adolescence. PROJECT NARRATIVE: This research is designed to provide a sound evidence base for surgical and orthodontic care of children with cleft lip and palate, the most common facial birth defect. This grant will serve to plan a clinical trial among five research centers to test whether an orthopedic, non-surgical treatment can be an alternative to surgery for these patients.