LATE MAXILLARY PROTRACTION FOR CLEFT LIP AND PALATE

描述(申请人提供)：这项计划拨款将用于在五个研究中心之间计划一项随机对照试验，以测试青少年上颌前牵引是否可以作为正颌外科手术的非手术替代方案，作为唇腭裂患者群体中骨骼下牙合的治疗方法。我们将比较在12-14岁接受上颌前牵引治疗的唇腭裂患者和在较晚年龄(通常为17-19岁)接受正颌外科手术的唇腭裂患者，当放射学和临床评估确定的颌骨生长停止时。进入上颌前牵引方案的患者将比手术患者得到更早的治疗。这项计划拨款将测试随机试验的可行性，并为一项长期研究提供基础，该研究将跟踪调查延长的患者，直到他们十几岁晚期，他们传统上会接受手术治疗，以研究发育迟缓和治疗复发对青春期上颌骨牵拉的影响。项目简介：这项研究旨在为唇腭裂儿童的手术和正畸护理提供可靠的证据基础，唇腭裂是最常见的面部出生缺陷。这笔赠款将用于在五个研究中心之间计划一项临床试验，以测试整形外科非手术治疗是否可以替代手术治疗。

DESCRIPTION (provided by applicant): This planning grant will serve to plan a randomized control trial among five research centers to test whether adolescent maxillary protraction can be a non-surgical alternative to orthognathic surgery as a treatment for a skeletal underbite in the cleft lip and palate patient population. We will compare cleft lip and palate patients treated with maxillary protraction at ages 12-14 with cleft lip and palate patients who undergo orthognathic surgery at a later age, usually ages 17-19, when jaw growth as determined by radiographic and clinical assessment, has ceased. The patients who enter the maxillary protraction protocol will be treated earlier than the surgery patients. This planning grant will test the feasibility of a randomized trial and provide the basis for a long-term study which would follow the protracted patients through their late teenage years when they would traditionally be treated with surgery in order to study the effects of late growth and treatment relapse on maxillary protraction during adolescence. PROJECT NARRATIVE: This research is designed to provide a sound evidence base for surgical and orthodontic care of children with cleft lip and palate, the most common facial birth defect. This grant will serve to plan a clinical trial among five research centers to test whether an orthopedic, non-surgical treatment can be an alternative to surgery for these patients.