Appalachian Tri-State NODE

本申请是为了响应RFA DA-05-001加入国家药物滥用研究所（NIDA） 临床试验网络（CTN）作为“阿巴拉契亚三州”（ATS）节点，与其他CTN节点合作， 在社区开展多中心临床试验。ATS将服务于一个重要的地理区域， 农村和服务不足的人口。该节点包括西方精神病研究所的一个研究小组， 匹兹堡大学医学中心的诊所（WPIC）与五个社区治疗合作 在西弗吉尼亚州，东俄亥俄州和西宾夕法尼亚州提供商（CTP）。临床的异质性 在这些CTP中服务的人群将允许CTP进行疗效和有效性试验， 提供者和临床人群的范围。ATS节点的组成部分包括：（1）经验丰富的团队 在农村和城市地区为多种类型药物滥用临床治疗中的不同患者群体提供服务的现金转拨方案的百分比 每年有超过13，000名患者参与的项目;（2）建立了研究基础设施， WPIC的区域研究治疗中心（RRTC）进行行为，药物治疗和 结合临床试验和相关活动;（3）强有力的培训和教育组成部分，可以提供 研究及临床训练，以及传播研究成果;（4）设立行政架构， ATS节点各组成部分之间的活动，并促进内部的最佳沟通与合作 （5）一系列技术转让、培训和 传播活动。在过去的四年里，RRTC和CTPs合作建立了一个 基础设施，建立双向通信，并进行两项试点研究。 我们的目标是：（1）开发和维护一个区域性的CTP网络，以参与临床试验，（2） 开发、指导和参与国家CTN的临床试验，（3）提供信息和培训 区域治疗提供者的机会，（4）制定、促进和实施治疗分配 努力，和（5）促进传播基于研究的治疗方法的发展 研究结果，以及将经过验证的评估和治疗方法纳入正在进行的 社区保健提供设施的活动。

This application is in response to RFA DA-05-001 to join the National Institute of Drug Abuse's (NIDA) Clinical Trials Network (CTN) as the "Appalachian Tri-State" (ATS) Node to work with other CTN Nodes to conduct multi-site clinical trials in the community. ATS will serve an important geographic area with many rural and underserved populations. This Node includes a research group at Western Psychiatric Institute and Clinic (WPIC) of the University of Pittsburgh Medical Center in partnership with five community treatment providers (CTPs) in West Virginia, Eastern Ohio and Western Pennsylvania. The heterogeneity of the clinical populations served in these CTPs will allow the CTP's to conduct efficacy and effectiveness trials with a range of providers and clinical populations. Components of the ATS Node include: (1) an experienced group of CTPs in rural and urban locations serving diverse groups of patients in many types of drug abuse clinical programs with access to over 13,000 patients annually; (2) an established research infrastructure within the Regional Research Treatment Center (RRTC) at WPIC for conducting behavioral, pharmacotherapy and combined clinical trials and related activities; (3) a strong training and education component that can provide research and clinical training and disseminate research findings; (4) an administrative structure to coordinate activities among the ATS Node components and to promote optimal communication and cooperation within the Node and with NIDA and the National CTN; and (5) a portfolio of technology transfer, training and dissemination activities. The RRTC and CTPs have collaborated during the past four years to build an infrastructure, establish bi-directional communication, and conduct two pilot studies. Our aims are to: (1) develop and maintain a regional network of CTPs to participate in clinical trials, (2) develop, direct, and participate in clinical trials for the National CTN, (3) provide information to, and training opportunities for regional treatment providers, (4) develop, promote, and implement treatment distribution efforts, and (5) contribute to the development of methods for dissemination of research-based treatment findings, and the integration of empirically-validated assessment and treatment methods into the ongoing activities of community healthcare delivery facilities.