MEDICATION DEVELOPMENT FOR COCAINE ABUSERS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在本报告所述期间，我们研究了各种苯基托烷类似物作为可卡因成瘾者的潜在药物。在过去的一年里，人们对选择性多巴胺转运体的各种3-苯基托烷的合成和性质进行了研究。除了表征这些新化合物外，我们还证明了许多这些化合物具有类似心理刺激的特性，这一点对于我们的目标来说是重要的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During the reporting period, we examined a variety of phenyltropane analogs of cocaine as potential medications for cocaine addicts. The synthesis and properties of various 3-phenyltropanes selective for the dopamine transporter were examined in the past year. In addition to characterizing these novel compounds, we have shown that many of these compounds have psychostimulant-like properties, which is important given our goal.