BEHAVIORAL DEVELOPMENT PRENATAL HORMONAL INFLUENCES

行为发展产前荷尔蒙的影响

• 批准号: 7715672
• 负责人: Kim Wallen
• 金额: $ 2.85万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715672
• 关键词: Adult; Affect; Aging; Anatomy; Androgen Receptor; Androgen Suppression; Androgens; Animals; Behavior; Behavioral; Body Weight; Brain; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Daily; Development; Environment; Exposure to; Female; Flutamide; Funding; Grant; Hormonal; Hormones; Injection of therapeutic agent; Institutes; Institution; Longevity; MRI Scans; Macaca mulatta; Mothers; Neurosecretory Systems; Pregnancy; Research; Research Personnel; Resources; Sex Characteristics; Source; Structure; Testosterone Enanthate; Thinking; United States National Institutes of Health; Week; day; design; male; mind control; prenatal; social

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The early hormone environment has been thought to influence the development of male/female behavioral and neuroendocrine differences through the life span. This study exposed developing male and female rhesus monkeys to atypical prenatal hormonal environments and has been investigating their behavioral and neuroendocrine development. Treatments were designed to mimic accidental exposure to or suppression of androgens prenatally. This study investigated whether prenatal androgen exposure, social rank, and body weight are factors regulating pubertal development in female rhesus monkeys. Subjects' mothers received injections of testosterone enanthate (20 mg/week), flutamide (an androgen receptor blocker, 30 mg/kg twice daily), or vehicle during gestational days 35/40-70 (early) or days 105/110-140 (late). We investigated whether reducing endogenous T prenatally affected adult copulatory behavior in male rhesus monkeys. Treatment with flutamide early in gestation resulted in males with significantly less masculinized genitals that control males or males getting flutamide late in gestation. During the current year all of the prenatally treated males and females along with concurrent controls were MRI scanned to look for sex differences in brain anatomy. In collaboration with investigators at the National Institute of Aging control MRI scans of males and females are being evaluated for structural sex differences. The prenatally treated animals are then being compared to the common morphed brains of control males and females to identify where prenatal treatments have modified brain structures.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 人们认为早期的激素环境会影响一生中男性/女性行为和神经内分泌差异的发展。 这项研究将发育中的雄性和雌性恒河猴暴露在非典型的产前荷尔蒙环境中，并一直在调查它们的行为和神经内分泌发育。 治疗的目的是模仿产前意外接触或抑制雄激素。 本研究调查了产前雄激素暴露、社会地位和体重是否是调节雌性恒河猴青春期发育的因素。 受试者的母亲在妊娠第 35/40-70 天（早期）或第 105/110-140 天（晚期）接受庚酸睾酮（20 毫克/周）、氟他胺（一种雄激素受体阻滞剂，30 毫克/千克，每天两次）或媒介物注射。 我们研究了产前减少内源 T 是否会影响雄性恒河猴成年后的交配行为。 妊娠早期使用氟他胺治疗会导致男性生殖器男性化程度显着降低，从而控制男性或男性在妊娠晚期接受氟他胺治疗。 今年，所有接受产前治疗的男性和女性以及同期对照组均接受了 MRI 扫描，以寻找大脑解剖结构的性别差异。 与国家衰老控制研究所的研究人员合作，正在评估男性和女性的 MRI 扫描的结构性性别差异。 然后将经过产前治疗的动物与对照雄性和雌性的常见变形大脑进行比较，以确定产前治疗在哪些地方改变了大脑结构。