Molecular interactions of novel conotoxin inhibitors of the noradrenaline transporter

去甲肾上腺素转运蛋白新型芋螺毒素抑制剂的分子相互作用

• 批准号: nhmrc : 143038
• 负责人: Prof David Adams
• 金额: $ 26.14万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-interactions-novel-noradrenaline-transporter/77751
• 关键词: Molecular; interactions; novel; conotoxin; inhibitors

A novel class of conotoxins (chi-conotoxins) has been discovered in the venom of an Australian cone snails, Conus marmoreus. Chi-conotoxins are the first peptide inhibitors of the noradrenaline transporter. From binding studies, it appears they act at a new site, remote from the site of action of antidepressants. This project is aimed at understanding how and where this novel class of peptide binds to the transporter. The results of this study are designed to maximise the potential of these patented peptides to be used as leads to the development of a new class of therapeutic for controlling the adverse effects of inadequate noradrenaline balance.

一种新的芋螺毒素类（chi-conotoxins）已被发现在澳大利亚锥螺，芋螺marmoreus的毒液。芋螺毒素是去甲肾上腺素转运蛋白的第一个肽类抑制剂。从结合研究来看，它们似乎作用于一个新的位点，远离抗抑郁药的作用位点。该项目旨在了解这种新型肽类如何以及在何处与转运蛋白结合。本研究的结果旨在最大限度地发挥这些专利肽的潜力，以开发一种新的治疗药物，用于控制去甲肾上腺素平衡不足的不良反应。