Electrophysiology facility for cell phenotyping and drug discovery

用于细胞表型分析和药物发现的电生理学设施

• 批准号: LE180100066
• 负责人: Prof David Adams
• 金额: $ 29.56万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Infrastructure, Equipment and Facilities
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LE180100066
• 关键词: Electrophysiology; facility; cell; phenotyping; drug

This project aims to establish a high-throughput, automated patch clamp facility to enable research at the forefront of cell phenotyping and drug discovery. Ion channels are membrane proteins that underlie cell function and are therefore important drug targets. The patch clamp technique is the most powerful tool available to functionally characterise cells and study the function of ion channels. The significant advance provided by the high-throughput, automated patch clamp system is that it allows up to 384 cells to be recorded simultaneously. This project expects to enhance capacity to automate and standardise the quality of recordings, substantially increase the rate of data production, and enable greater access to patch clamp technology.

该项目旨在建立一个高通量、自动化的膜片钳设备，使研究处于细胞表型和药物发现的前沿。离子通道是细胞功能基础的膜蛋白，因此是重要的药物靶点。膜片钳技术是功能表征细胞和研究离子通道功能的最有力的工具。高通量、自动化膜片钳系统提供的重大进步是，它允许同时记录多达384个细胞。该项目预计将提高录音质量自动化和标准化的能力，大幅提高数据生产速度，并使膜片钳技术得到更广泛的应用。