Automated Patch Clamp System

自动化膜片钳系统

• 批准号: LE0775613
• 负责人: Prof David Adams
• 金额: $ 31.14万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Infrastructure, Equipment and Facilities
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-02-21 至 2008-02-20
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LE0775613
• 关键词: Automated; Patch; Clamp; System

Ion channels are membrane proteins that underlie cell function and are therefore important drug targets. The patch clamp technique is the most powerful tool available to study the function of single ion channels. The recent automation of this technology represents a quantum leap in our ability to perform high throughput screening of novel natural and synthetic compounds as drug leads. This will lead to an urgently needed increase in capacity, increasing the volume of research and its outcomes, which will benefit the Australian pharmaceutical industry and biosciences research community.

离子通道是细胞功能的膜蛋白，因此是重要的药物靶点。膜片钳技术是研究单离子通道功能的最有力的工具。这项技术的最新自动化代表了我们对作为药物先导的新型天然和合成化合物进行高通量筛选的能力的巨大飞跃。这将导致迫切需要的能力增加，增加研究量及其成果，这将有利于澳大利亚制药业和生物科学研究界。