Neural substrate of language and social cognition: autism and typical development

描述(申请人提供)：自闭症是一种以语言和社会认知障碍为特征的发育障碍。尽管有很多关于成人自闭症的神经生物学基础的研究，但很少有研究在发育框架内考察神经基础。少数几项研究往往分别关注语言或社会认知的神经基础，而不是两者兼而有之。虽然语言和社会认知传统上被视为独立的行为领域，但来自典型儿童的行为证据表明，语言习得依赖于社会过程，如对照顾者的共同注意请求做出反应。在自闭症患者中，联合注意力缺陷是严重的，并与后来的语言障碍相关。这项建议的目标是确定在典型发育和自闭症谱系障碍(ASD)儿童中，社会和语言处理的共同和独特的神经底物。 为了实现这一目标，我们将从24名典型成人(12名男性，12名女性)、24名典型5-8岁儿童(12名男性，12名女性)、24名典型9-12岁儿童(12名男性，12名女性)和15名9-12岁患有自闭症谱系障碍(ASD)的儿童(12名男性，3名女性)获得功能磁共振成像(FMRI)数据。将进行分析，以确定这些独立任务背后的神经基础，以及同一受试者内这些任务之间共享的神经重叠量。通过这种设计，可以进行典型发展中的年龄和性别相关分析，以及自闭症中的年龄和表现相关分析。15名自闭症儿童(12名男性，3名女性)将与两个性别匹配的对照组进行比较：一个年龄匹配的对照组(9-12岁)和一个表现匹配的对照组(5-8岁)。自闭症儿童的对照组将由典型发育儿童的子集组成。公共卫生相关性：通过在同一提案中处理典型和非典型发展的问题，可以更深入地了解自闭症社会和语言发展背后的异常发展轨迹。明确ASD中这些原发性缺陷的共同神经基础可能有助于指导早期干预，并提供集中的神经区域，以帮助寻找这些缺陷的共同微结构和遗传基础。

DESCRIPTION (provided by applicant): Autism is a developmental disorder characterized by impairments in both language and social cognition. Despite much research on the neurobiological underpinnings of autism in adults, very few studies have examined the neural bases within a developmental framework. Those few studies that have often focus on the neural bases underlying either language or social cognition separately, but not both. Although language and social cognition are traditionally examined as independent behavioral domains, behavioral evidence from typical children suggests that language acquisition depends on social processes, such as responding to joint attention bids from a caregiver. In autism, joint attention deficits are severe and correlate with later language impairments. The goal of this proposal is to identify the shared and distinct neural substrates for social and language processing in typical development and in children with autism spectrum disorder (ASD). To achieve this goal, functional magnetic resonance imaging (fMRI) data will be acquired from 24 typical adults (12 male, 12 female), 24 typical 5-8 year-old children (12 male, 12 female), 24 typical 9-12 year-old children (12 male, 12 female), and 15 9-12 year-old children with autism spectrum disorder (ASD) (12 male, 3 female) during performance of two separate tasks: responding to joint attention bids and narrative comprehension. Analyses will be conducted to identify the neural bases underlying these separate tasks as well as the amount of shared neural overlap between these tasks within the same subjects. With this design age- and gender-related analyses in typical development and age- and performance-related analyses in autism can be conducted. The 15 ASD children (12 male, 3 female) will be compared to two gender-matched control groups: one age-matched control group (9-12 years) and one performance-matched control group (5-8 years). The control groups for the ASD children will be comprised of a subset of the typically developing children. PUBLIC HEALTH RELEVANCE: By addressing questions of both typical and atypical development in the same proposal, greater insights can be gained into the aberrant developmental trajectory underlying both social and linguistic development in ASD. Pinpointing the common neural bases of these primary deficits in ASD may help to guide early intervention and provide neural regions of focus to aid in the search for shared microstructural and genetic bases of these deficits.