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Brain Network Dynamics Contributing to Atypical Social Interaction in Autism

大脑网络动力学导致自闭症患者的非典型社交互动

基本信息

批准号：
9918454
负责人：
Elizabeth Redcay
金额：
$ 50.03万
依托单位：
UNIV OF MARYLAND, COLLEGE PARK
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-11 至 2022-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9918454
关键词：
12 year old Address Age Behavior Behavior assessment Behavioral Brain Characteristics Child Cognitive Data Development Diagnostic Disease Divorce Face Functional Magnetic Resonance Imaging Gender Goals Gold Graph Impairment Incentives Individual Individual Differences Intervention Knowledge Link MRI Scans Maps Measures Medial Methods Mission Motivation National Institute of Mental Health Neurobiology Neurosciences Parents Pathway Analysis Play Prefrontal Cortex Reciprocal Social Interaction Reporting Research Rest Rewards Risk Marker Role Social Behavior Social Development Social Interaction Structure Support System System Techniques Testing Time Ventral Striatum age related autism spectrum disorder autistic children base cognitive system cognitive task data acquisition disability financial incentive innovation insight mental state middle childhood neural circuit neurodevelopment neuroimaging neuromechanism novel programs recruit relating to nervous system reward anticipation reward circuitry reward processing social social deficits social organization social relationships social skills theories

项目摘要

Atypical reciprocal social interaction is a core diagnostic feature of autism spectrum disorder (ASD), but the brain network dynamics contributing to difficulties with social interactions remain unclear. Dominant theories suggest a role for social-motivational and social-cognitive brain networks. However, these theories have been tested in neuroimaging contexts divorced from social interaction (i.e., viewing photos of strangers). Because these detached, offline measures fail to capture the real-world social-interactive challenges faced by individuals with ASD, the critical question of what neural mechanisms underlie atypical social interaction remains unanswered. The current proposal takes an innovative, interactive approach by examining real-time social interaction during fMRI data acquisition to characterize the development and interaction of motivational (i.e., reward) and social-cognitive brain networks during middle childhood. Middle childhood presents an opportune time to address this question because this age is marked by increased social competence in neurotypical (NT) children but plateauing social abilities in ASD. At the neural level, middle childhood is a time of significant change in social brain networks in NT but relatively little data speak to these changes in ASD. Our central hypothesis is that atypical organization of social-motivational and social-cognitive networks during real- time social interactions predict social-interactive difficulties in autism. We will test this hypothesis with the following specific aims in NT and ASD children: 1) determine whether approval from a real-time social partner modulates motivational systems and 2) determine whether real-time social interaction modulates social- cognitive systems, and 3) determine how interactions between motivational and social-cognitive networks during real-time social interaction relate to measures of real-world social behaviors. To achieve these aims, 70 NT and 54 ASD children (7-12 years of age) will participate in a social reward and a social cognitive task in which they engage with an experimenter in real time during functional MRI data acquisition. Graph theoretic measures will be used to examine network organization and interactions within motivational and social- cognitive brain networks during the social interaction task and at rest. Successful completion of the proposed research will advance our understanding of how reward and social-cognitive networks are modulated by real- time social interaction in children with ASD and whether atypical modulation of these networks is related to real-world social impairments. These contributions will be significant to the scientific field and relevant to the strategic mission of NIMH because they will 1) provide critical missing information about the development of brain mechanisms underlying social interaction, 2) determine how individual differences in these brain circuits map onto directly observable behavior, and 3) examine differences in the course and mechanism of functional brain development between neurotypical and ASD children, which will address questions of how, when, and where to intervene.

非典型互惠社会互动是自闭症谱系障碍（ASD）的核心诊断特征

项目成果

期刊论文数量（13）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Social reward network connectivity differs between autistic and neurotypical youth during social interaction.

在社交互动过程中，自闭症青少年和神经正常青少年的社会奖励网络连接有所不同。

DOI：
10.1101/2023.06.05.543807
发表时间：
2023
期刊：
bioRxiv : the preprint server for biology
影响因子：
0
作者：
Xie,Hua;Moraczewski,Dustin;McNaughton,KathrynA;Warnell,KatherineR;Alkire,Diana;Merchant,JunaidS;Kirby,LauraA;Yarger,HeatherA;Redcay,Elizabeth
通讯作者：
Redcay,Elizabeth