Neurocognitive Risk For Alcoholism Into Adulthood

成年期酗酒的神经认知风险

• 批准号: 7456583
• 负责人: ROBERT ALPERT ZUCKER
• 金额: $ 59.82万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7456583
• 关键词: Adolescence; Adolescent; Adult; Age; Alcohol abuse; Alcohol consumption; Alcoholism; Alcohols; Back; Behavior; Behavioral; Biological Neural Networks; Brain; Brain region; Child; Childhood; Clinical; Comorbidity; Computer information processing; Control Groups; Corpus striatum structure; Data; Development; Discrimination; Disease; Drops; Drug abuse; Drug usage; Exhibits; Family; Family Study; Female; Functional Magnetic Resonance Imaging; Functional disorder; Grant; Hand; Individual; Individual Differences; Link; Longitudinal Studies; Maps; Measurement; Measures; Mediating; Michigan; Nature; Neurocognition; Neurocognitive; Neurophysiology - biologic function; Nursery Schools; Outcome; Parents; Participant; Pattern; Performance; Personal Satisfaction; Pharmaceutical Preparations; Process; Prospective Studies; Protocols documentation; Regulation; Relative (related person); Research Personnel; Rewards; Risk; Risk Factors; Risk-Taking; Role; Sampling; Short-Term Memory; Smoking; Substance Use Disorder; System; Teenagers; Temperament; Time; Work; Youth; alcohol and other drug; alcohol use disorder; base; career; design; disorder risk; drinking; drug of abuse; early childhood; emotion regulation; executive function; interest; male; model development; neurodevelopment; neuropsychological; non-alcoholic; problem drinker; programs; prospective; relating to nervous system; response; social; trait; underage drinking

The aim of this continuation project is to characterize how early and mid adolescent neurocognitive functioning, in the context of an emerging drinking career, serves to increase risk for the emergence of alcohol use disorder. 899 participants from an ongoing longitudinal study of at risk children, who had neurocognitive assessments in early adolescence during the prior grant period, will move from late adolescence into their early twenties during the current project. During this crucial developmental transition the heaviest levels of alcohol and other drug use can be expected. The project's conceptual framework integrates three broad functional neural networks theorized to be involved in alcoholism and other drug abuse which will be assessed via performance measures: (a) executive functioning, especially response suppression and working memory, (b) reward response, including anticipation of reward and response to reward, and (c) secondarily, right hemisphere function, with discrimination between spatial and social information processing. Bi-directional behavior-neurocognitive effects will be considered. Neural functioning will also be characterized directly, via fMRI, to examine: (1) individual differences in brain functioning in relation to alcohol/drug use, neurocognitive performance, and earlier neurocognitive weakness; and (2) changes in brain functioning over time with increasing drug use, also assessed in relation to earlier neurocognitive weakness. Tasks involving the two core domains of the proposal, executive functioning and reward response, will be used to activate brain regions of interest. We will characterize differences in neural development in the late teens and again two years thereafter?as the frontal circuitry of interest matures?in 120 selected youth from the larger study. This design will enable determination of whether neural activation patterns are similar, with and without performance decrements, and in relation to alcohol/drug use during the intervening 2 years. The project will be carried out in a well characterized longitudinal sample of male and female children of alcoholics along with an ecologically comparable but nonalcoholic group of controls who have been assessed at three year intervals since early childhood. Neurocognitive assessments will be carried out at 3 year intervals, and the fMRI protocol is to be administered twice.

该延续项目的目的是描述青少年早期和中期的神经认知功能在新兴饮酒职业的背景下如何增加出现酒精使用障碍的风险。一项正在进行的针对高危儿童的纵向研究中的 899 名参与者在上一个资助期间在青春期早期接受了神经认知评估，他们将在当前项目期间从青春期后期进入二十岁出头。在这个关键的发育转变期间，酒精和其他药物的使用量可能会达到最高水平。 该项目的概念框架整合了理论上与酗酒和其他药物滥用有关的三个广泛的功能神经网络，这些神经网络将通过绩效衡量进行评估：（a）执行功能，特别是反应抑制和工作记忆，（b）奖励反应，包括对奖励的预期和对奖励的反应，以及（c）其次是右半球功能，区分空间和社会信息处理。将考虑双向行为神经认知效应。还将通过功能磁共振成像直接表征神经功能，以检查：（1）与酒精/药物使用、神经认知表现和早期神经认知无力相关的大脑功能的个体差异； (2)随着时间的推移，随着药物使用的增加，大脑功能发生变化，也与早期神经认知无力相关进行评估。涉及该提案的两个核心领域（执行功能和奖励反应）的任务将用于激活感兴趣的大脑区域。我们将从更大范围的研究中选出 120 名青少年，描述青少年晚期以及两年后（随着感兴趣的额叶回路成熟）神经发育的差异。该设计将能够确定神经激活模式是否相似，有或没有表现下降，以及与干预两年期间酒精/药物使用的关系。该项目将在一个明确特征的纵向样本中进行，样本包括酗酒者的男性和女性儿童，以及生态上可比但不酗酒的对照组，这些对照组从幼儿期起每三年进行一次评估。神经认知评估将每 3 年进行一次，功能磁共振成像方案将进行两次。