HCV CENTER STUDIES ON INFECTIOUS HCV

HCV 中心关于传染性 HCV 的研究

• 批准号: 7716082
• 负责人: Robert E LANFORD
• 金额: $ 0.39万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716082
• 关键词: Antiviral Agents; Chronic; Cirrhosis; Computer Retrieval of Information on Scientific Projects Database; Development; Funding; Goals; Grant; Hepatitis C; Hepatitis C virus; Individual; Infection; Infectious hepatitides; Institution; Liver diseases; Malignant neoplasm of liver; Molecular; Molecular Cloning; Pan Genus; Pan troglodytes; Population; Research; Research Personnel; Resources; Ribavirin; Source; Testing; United States National Institutes of Health; Vaccines; Viral; improved; interferon therapy; tissue culture

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Approximately 2% of the US population in chronically infected with hepatitis C virus (HCV). Chronic HCV infections result in significant liver disease including cirrhosis and liver cancer in approximately 20%of infected individuals. The current therapy of interferon and ribavirin does not result in viral clearance in the majority of cases. A better understanding of the replication of HCV at a molecular level as well as the factors that determine whether an infection will proceed to chronic infection or viral clearance are essential for the development of improved antiviral strategies. These studies are important for both vaccine and antiviral development. This is subcontract from the SOUTHEASTERN COOPERATIVE HEPATTIS C RESEARCH GROUP (0024). The goal was to test a molecular clone of HCV that replicates in tissue culture for replication in chimpanzees.

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