AFFECTIVE AND NEUROBIOLOGICAL PREDICTORS OF ADOLESCENT-ONSET ALCOHOL USE DISORDE

青少年酒精使用障碍的情感和神经生物学预测因素

• 批准号: 7718753
• 负责人: DOUGLAS E WILLIAMSON
• 金额: $ 0.35万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718753
• 关键词: Address; Adolescence; Adolescent; Affect; Affective; Alcohol consumption; Arousal; Behavioral; Clinical; Computer Retrieval of Information on Scientific Projects Database; Development; Early Intervention; Environmental Risk Factor; Funding; Genetic; Goals; Grant; Institution; Longitudinal Studies; Mediating; Mental Depression; Modeling; Moods; Neurobiology; Pathway interactions; Research; Research Personnel; Resources; Risk; Social Policies; Source; Testing; United States National Institutes of Health; Work; Youth; alcohol use disorder; design; neural circuit; prospective

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-term goals of this work are to address questions with great clinical and social policy relevance - understanding developmental pathways and mechanisms of vulnerabiity that can inform early interventions for adolescent-onset alcohol use disorders (AUD), especially those targeting youth with affective vulnerabilities. The short-term goals are to test key features of a developmental model focusing on elected genetic, environmental, behavioral and neurobiological factors as they impact risk for developing AUD during adolescence. The design includes cross-sectional compraisons as well as a prospective longitudinal study of young adolescents with high and low familial loading for depression (HIGH-DEP vs. LOW_DEP) followed from mid to late adolescence. There are four sepcific aims of this research: 1. To examine the impact of familial loading for depression on the risk to develop AUD during adolescence. 2. To examin the effects of familial loading for expression on underlying neural circuits related to mood and affect - especially those mediating behavioral and physiologc arousal and affective control - and their association with the risk to develop AUD duing adolescence. 3. To examine the specific contributions of genetic and environmental risk factors for the risk to develop AUD during adolescence. 4. To examine prospectively the effect of developing AUD on neural circuitry involved in affective arousal and control.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项工作的长期目标是解决具有重大临床和社会政策相关性的问题-了解可持续性的发展途径和机制，这些途径和机制可以为酒精使用障碍（AUD）的早期干预提供信息，特别是针对情感脆弱的青少年。 短期目标是测试发展模型的关键特征，重点是选定的遗传，环境，行为和神经生物学因素，因为它们影响青春期发展AUD的风险。 该设计包括横断面比较以及前瞻性纵向研究的年轻青少年与高和低家庭负荷抑郁症（高DEP与低DEP），从中期到后期的青春期。 本研究有四个具体目标： 1. 研究抑郁症的家庭负荷对青少年期发生AUD风险的影响。 2. 研究家族表达负荷对与情绪和情感相关的潜在神经回路的影响，尤其是那些介导行为和生理唤醒以及情感控制的神经回路，以及它们与青春期发生AUD风险的关系。 3. 研究遗传和环境风险因素对青春期发生AUD风险的具体贡献。 4. 前瞻性研究发展AUD对情感唤醒和控制相关神经回路的影响。