DEPRESSION AND ENDOTHELIAL FUNCTION IN POSTMENOPAUSAL WOMEN

绝经后女性的抑郁和内皮功能

• 批准号: 7719128
• 负责人: JULIE A WAGNER
• 金额: $ 0.8万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719128
• 关键词: Age; Attenuated; Back; Behavior; Computer Retrieval of Information on Scientific Projects Database; Controlled Study; Coronary heart disease; Depressed mood; Diagnostic; Dose; Functional disorder; Funding; Gold; Grant; Impairment; Institution; Interview; Longevity; Major Depressive Disorder; Mediating; Mental Depression; Methods; Numbers; Postmenopause; Rate; Relative (related person); Research; Research Personnel; Resources; Risk Factors; Source; Standards of Weights and Measures; TimeLine; United States National Institutes of Health; Woman; bone; brachial artery; depressive symptoms; experience; heart disease risk; indexing; male; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Major depressive disorder is a well-established risk factor for incident coronary heart disease and women have higher rates of major depressive disorder than their male counterparts. Endothelial functioning is impaired during current depressive episode. However, it is unknown whether this impairment continues once the depressive episode resolves. The overarching question this study asks is whether previous (but specifically not current) major depressive disorder is associated with endothelial dysfunction in post-menopausal women. This retrospective, controlled study will investigate the relationship between previous major depressive disorder and current coronary heart disease risk in postmenopausal women who are matched for age and Bone Mass Index (BMI). The independent variable is previous major depressive disorder. A reliable, valid, and widely used method for assessing previous behaviors, the timeline follow back method, has been adapted for use with the gold standard diagnostic interview (SCID) to assess previous major depressive disorder. The dependent variable is brachial artery flow mediated dilation. Specific aims are to: 1. Determine whether currently nondepressed women who have experienced previous major depressive disorder have impaired flow mediated dilation relative to their never depressed counterparts. We hypothesize that currently non-depressed women who have experienced previous major depressive disorder will have impaired flow mediated dilation relative to their never depressed counterparts. 2. Determine whether there is a 'dose-response' relationship between number of depressive episodes over the lifespan and flow mediated dilation. We hypothesize that more depressive episodes over the lifespan will be related to decreased flow mediated dilation. 3. Determine whether treatment for depression attenuates any deleterious effects that depression exerts on flow mediated dilation. We hypothesize that previously depressed women whose depression was treated pharmacologically will have less impaired flow mediated dilation than their counterparts whose depression was untreated.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 重度抑郁症是冠心病事件的一个公认的危险因素，女性患重度抑郁症的比例高于男性。 当前抑郁发作期间内皮功能受损。 然而，尚不清楚一旦抑郁发作消退，这种损害是否会继续。这项研究提出的首要问题是，绝经后妇女既往（但不是当前）重度抑郁症是否与内皮功能障碍有关。 这项回顾性对照研究将调查年龄和骨量指数（BMI）匹配的绝经后妇女中既往重度抑郁症和当前冠心病风险之间的关系。自变量为既往重度抑郁症史。时间轴追踪法是一种可靠、有效且广泛使用的评估既往行为的方法，已与金标准诊断访谈（SCID）一起用于评估既往重度抑郁障碍。因变量为肱动脉血流介导的舒张。具体目标是： 1. 确定是否目前非抑郁的妇女谁经历过以前的抑郁症有受损的血流介导的扩张相对于他们从来没有抑郁的同行。我们假设，目前非抑郁症的妇女谁经历过以前的严重抑郁症将有受损的流量介导的扩张相对于他们从来没有抑郁的同行。 2. 确定是否有一个“剂量反应”之间的关系抑郁发作的数量在整个生命周期和流量介导的扩张。我们假设，在生命周期中更多的抑郁发作将与血流介导的扩张减少有关。 3. 确定抑郁症的治疗是否减弱抑郁症对血流介导的扩张的任何有害影响。 我们假设，以前抑郁症的妇女抑郁症治疗后，将有较少受损的血流介导的扩张比他们的同行抑郁症是未经治疗的。