General Clinical Research Center

描述（由申请人提供）：自1977年以来，GCRC一直是支持和发展MUSC研究企业的关键因素。在此期间，GCRC促进了MUSC研究和研究培训活动的非凡增长。本申请中详细的科学发现、出版记录、调查人员名单和协议提供了GCRC在MUSC校园的生产力和重要性的证据。认识到这一点，对GCRC的机构支持非同寻常、意义重大且持续不断。在这个竞争性的更新申请中，我们描述了GCRC领导团队的人员和结构的主要变化，以及提供的服务，旨在巩固和扩大GCRC在促进和催化全校范围内的临床和转化研究方面的作用。培训和教育活动包括GCRC参与校园范围内的重点培训计划，如MUSC的多学科路线图T32临床博士前研究培训计划和新创建的转化系列讲座，其中基础和临床科学家分享讲台，展示合作转化研究。在研究支援服务方面，GCRC已作出重大努力，征求用户的意见，并根据这些意见作出改进。我们描述了几个方面的改进，旨在提高GCRC申请过程的便利性，并提供基本协议管理方面的帮助，如监管和招聘支持。核心实验室的活动已扩大到包括开发新的分析技术和启用100,000级洁净室（ISO 7）作为GCRC核心实验室设施。我们将继续战略性地发展服务，促进、催化和支持高水平的临床和转化研究以及研究培训。MUSC已经获得了P20计划拨款的资金，用于在明年制定临床和转化科学奖提案。GCRC将是这一倡议的规划和发展的组成部分。

DESCRIPTION (provided by applicant): The GCRC has been a critical element in the support and growth of the MUSC research enterprise since 1977. During this period, the GCRC has facilitated extraordinary growth in MUSC's research and research training activities. The scientific discoveries, publication track record, list of investigators and protocols detailed in this application provide evidence of the productivity and importance of the GCRC on the MUSC campus. In recognition of this, the institutional support for the GCRC has been extraordinary, significant and sustaining. In this competing renewal application, we describe major changes in personnel and structure of the GCRC leadership team and services offered which are designed to solidify and expand the role of the GCRC in facilitating and catalyzing clinical and translational research campus-wide. Training and educational activities include GCRC involvement in key training programs campus-wide such as MUSC's multidisciplinary Roadmap T32 clinical predoctoral research training program and a newly created translational lecture series in which basic and clinical scientists share the podium in presenting collaborative translational research. In research support services, the GCRC has made significant efforts to solicit feedback from users and make improvements based on this feedback. We describe improvements in several areas designed to increase the ease of the GCRC application process and provide assistance with basic protocol management such as regulatory and recruitment support. Core Laboratory activities have been expanded to include the development of new assay techniques and the activation of a Class 100,000 clean room (ISO 7) as a GCRC Core laboratory facility. We will continue strategic efforts to develop services that facilitate, catalyze and support high caliber clinical and translational research and research training. MUSC has received funding for a P20 planning grant to develop a Clinical and Translational Science Award proposal over the next year. The GCRC will be integral to the planning and development of this initiative.