EFFECT OF ACETAMINOPHEN (TYLENOL) ON HUMAN LYMPHOCYTES

对乙酰氨基酚（泰诺）对人体淋巴细胞的影响

• 批准号: 7716857
• 负责人: PAUL B WATKINS
• 金额: $ 0.29万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-02 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716857
• 关键词: Acetaminophen; Authorization documentation; Blood; Clinical Research; Complement; Computer Retrieval of Information on Scientific Projects Database; Enrollment; Funding; Grant; Human; In Vitro; Individual; Injury; Institution; Laboratories; Learning; Liver; Lymphocyte; Natural History; Pharmaceutical Preparations; Protocols documentation; Research; Research Personnel; Resources; Source; Tylenol; United States National Institutes of Health; base; cohort; design; programs; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. As part of the PI's research program in drug-induced liver injury, protocols GCRC #2122, 2228, 2265 have been designed to further define the natural history and mechanisms os drug-induced liver injury in humans. As a complement to these clinical studies, the investigative team has been developing laboratory-based protocols to learn more about potential mechanisms of injury. A specific example is exploring the effect of acetaminophen on lymphocytes. This proposal seeks permission to enroll a cohort of 30 individuals who are willing to donate blood repeatedly over the course of the study to be used for these in vitro experiments.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 作为 PI 药物性肝损伤研究计划的一部分，GCRC #2122、2228、2265 方案旨在进一步定义人类药物性肝损伤的自然史和机制。 作为这些临床研究的补充，研究小组一直在开发基于实验室的方案，以更多地了解潜在的损伤机制。 一个具体的例子是探索对乙酰氨基酚对淋巴细胞的影响。 该提案寻求许可招募 30 名愿意在研究过程中反复献血的个体，用于这些体外实验。