ACETAMINOPHEN (TYLENOL?) INDUCED HUMAN LYMPHOCYTE TOXICITY

对乙酰氨基酚（泰诺？）引起的人体淋巴细胞毒性

• 批准号: 7716902
• 负责人: PAUL B WATKINS
• 金额: $ 0.01万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-02 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716902
• 关键词: Acetaminophen; Biological Assay; Cell Survival; Computer Retrieval of Information on Scientific Projects Database; Flow Cytometry; Funding; Grant; Human; In Vitro; Institution; Learning; Lymphocyte; Methods; Participant; Peripheral; Procedures; Purpose; Research; Research Personnel; Resources; Source; Toxic effect; Tylenol; United States National Institutes of Health; cell injury; design; drug mechanism; healthy volunteer; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Purpose: This study was designed to learn more about potential mechanisms of drug-induced cellular injury. Human lymphocytes from healthy volunteers will be obtained. In-vitro experiments will be carried out in peripheral lymphocytes to assess intra-subject and inter-subject variability in sensitivity to acetaminophen toxicity. Participants: 100 Healthy Volunteers Procedures (methods): In vitro cell viability assays and flow cytometry will be used to assess lymphocyte sensitivity to toxicity caused by acetaminophen

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 目的：本研究旨在更多地了解药物诱导的细胞损伤的潜在机制。 将获得来自健康志愿者的人类淋巴细胞。 体外实验将在外周淋巴细胞中进行，以评估对乙酰氨基酚毒性敏感性的受试者内和受试者间变异性。 参与者：100名健康志愿者 程序（方法）：将使用体外细胞活力测定法和流式细胞仪来评估乙酰氨基酚引起的淋巴细胞敏感性