ACETAMINOPHEN (TYLENOL?) INDUCED HUMAN LYMPHOCYTE TOXICITY

对乙酰氨基酚（泰诺？）引起的人体淋巴细胞毒性

• 批准号: 7716902
• 负责人: PAUL B WATKINS
• 金额: $ 0.01万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-02 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716902
• 关键词: Acetaminophen; Biological Assay; Cell Survival; Computer Retrieval of Information on Scientific Projects Database; Flow Cytometry; Funding; Grant; Human; In Vitro; Institution; Learning; Lymphocyte; Methods; Participant; Peripheral; Procedures; Purpose; Research; Research Personnel; Resources; Source; Toxic effect; Tylenol; United States National Institutes of Health; cell injury; design; drug mechanism; healthy volunteer; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Purpose: This study was designed to learn more about potential mechanisms of drug-induced cellular injury. Human lymphocytes from healthy volunteers will be obtained. In-vitro experiments will be carried out in peripheral lymphocytes to assess intra-subject and inter-subject variability in sensitivity to acetaminophen toxicity. Participants: 100 Healthy Volunteers Procedures (methods): In vitro cell viability assays and flow cytometry will be used to assess lymphocyte sensitivity to toxicity caused by acetaminophen

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：本研究旨在了解更多的药物诱导细胞损伤的潜在机制。 将从健康志愿者中获得人淋巴细胞。 将在外周淋巴细胞中进行体外实验，以评估对乙酰氨基酚毒性敏感性的受试者内和受试者间变异性。 参与者：100名健康志愿者 程序（方法）：体外细胞活力测定和流式细胞术将用于评估淋巴细胞对乙酰氨基酚引起的毒性的敏感性