HOST DNA METHYLATION PATTERNS IN ASSOCIATION WITH PERIODONTAL DISEASE
HOST DNA METHYLATION PATTERNS IN ASSOCIATION WITH PERIODONTAL DISEASE
批准号:
7716921
负责人:
Steven Offenbacher
金额:
$0.04万
依托单位国家:
美国
项目类别:
财政年份:
2008
资助国家:
美国
项目状态:
已结题
起止时间:
2008-04-02 至 2008-05-31
关键词:
BiologicalBiopsyBiopsy SpecimenChronicClinicalCollectionComputer Retrieval of Information on Scientific Projects DatabaseDNA MethylationDental CareDental ClinicsDental FacultyDental SchoolsDental crownsDepthExhibitsFundingGene Expression AlterationGingivaGingival Crevicular FluidGoalsGrantHealthHemorrhageInflammationInstitutionMeasurementMethodsMethylationNorth CarolinaOralParticipantPatientsPatternPeriodontal DiseasesPeriodontic specialtyPeriodontitisProceduresPurposeRecruitment ActivityResearchResearch PersonnelResourcesSamplingSchool DentistryScoreScreening procedureSourceSpecimenSurgical FlapsTimeTissuesTooth structureUnited States National Institutes of HealthUniversitiesVenipuncturesVisitWhole Blooddaysample collection
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Purpose: The overall goal of this research is to identify changes in gene expression and alterations of DNA methylation status in subjects who exhibit advanced chronic periodontal inflammation.
Participants: Thirty subjects will be recruited from Graduate Periodontics Clinic and Dental Faculty Practice at the University of North Carolina School of Dentistry. Fifteen subjects will exhibit advanced chronic periodontitis (diseased), and 15 will exhibit periodontal health (healthy).
Procedures (methods): The following procedures will be performed during the visit(s), with the restriction that all biological specimens will be collected on the same day, or that all biological specimens except the biopsy (ies) will be taken on one day and the biopsy (ies) on the next day: an oral and periodontal screening exam, approximately 40 ml of whole blood will be collected via venipuncture, collection of 16 gingival crevicular fluid samples,
collection of subgingival plaque sample(s), all teeth will be scored for pocket depth, percent bleeding on probing and clinical attachment level unless the patient s dental school chart has these recent (within six months) measurements. In addition, one gingival biopsy sample per
healthy subject will be collected at the time of a routine crown extension procedure, and two gingival biopsy samples will be obtained from periodontitis subjects at the time of a periodontal flap procedure. All biopsy samples are tissues that would otherwise be discarded during the dental procedures.
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会议论文
Role of IL-37 Genetic Variants in Modulating Innate Immune Resp to Periodontal Pa
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批准号:8760439
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项目类别:
-
资助金额:$37.75万
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财政年份:2014
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负责人:Steven Offenbacher
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依托单位:
Role of IL-37 Genetic Variants in Modulating Innate Immune Resp to Periodontal Pa
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批准号:8898051
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项目类别:
-
资助金额:$37.74万
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财政年份:2014
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负责人:Steven Offenbacher
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依托单位:
GENOME-WIDE ASSOCIATION STUDY OF PERIODONTAL DISEASE
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批准号:8289448
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项目类别:
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资助金额:$32.58万
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财政年份:2011
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负责人:Steven Offenbacher
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依托单位:
GENOME-WIDE ASSOCIATION STUDY OF PERIODONTAL DISEASE
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批准号:8023292
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项目类别:
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资助金额:$33.2万
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财政年份:2011
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负责人:Steven Offenbacher
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依托单位:
CLINICAL TRIAL: EXPLORATORY PROTEOMIC ANALYSES OF GINGIVAL CREVICULAR FLUID IN H
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批准号:7716896
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项目类别:
-
资助金额:$1.16万
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财政年份:2008
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负责人:Steven Offenbacher
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依托单位:
ANTI-INFLAMMATORY PROPERTIES OF TRICLOSAN: TRICLOSAN ANTI-INFLAMMATORY (TAU))
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批准号:7716875
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项目类别:
-
资助金额:$0.18万
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财政年份:2008
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负责人:Steven Offenbacher
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依托单位:
SCREENING EXAMINATION IN THE GO HEALTH CENTER
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批准号:7716831
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项目类别:
-
资助金额:$0.02万
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财政年份:2008
-
负责人:Steven Offenbacher
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依托单位:
MOTOR: MATERNAL ORAL THERAPY TO REDUCE OBSTETRIC RISK
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批准号:7716784
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项目类别:
-
资助金额:$7.32万
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财政年份:2008
-
负责人:Steven Offenbacher
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依托单位:
CLINICAL TRIAL: EFFICACY AND SAFETY OF A NOVEL PROTOTYPE POWER TOOTHBRUSH EVALUA
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批准号:7716879
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项目类别:
-
资助金额:$2.87万
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财政年份:2008
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负责人:Steven Offenbacher
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依托单位:
CROSS-SECTIONAL STUDY OF CANDIDATE PREDICTOR BIOMARKERS IN HLTHY VS PERIOD SU
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批准号:7625610
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项目类别:
-
资助金额:$0.6万
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财政年份:2006
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负责人:Steven Offenbacher
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依托单位:
EXPLORATORY PROTEOMIC ANALYSES OF GINGIVAL CREVICULAR FLUID IN HUMAN GINGIVITIS
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批准号:7625679
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项目类别:
-
资助金额:$0.75万
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财政年份:2006
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负责人:Steven Offenbacher
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依托单位:
SCREENING EXAMINATION IN THE GO HEALTH CENTER
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批准号:7625627
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项目类别:
-
资助金额:$0.06万
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财政年份:2006
-
负责人:Steven Offenbacher
-
依托单位:
MOTOR: MATERNAL ORAL THERAPY TO REDUCE OBSTETRIC RISK
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批准号:7625561
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项目类别:
-
资助金额:$21.59万
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财政年份:2006
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负责人:Steven Offenbacher
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依托单位:
COHORT STUDY OF CANDIDATE PREDICTOR BIOMARKERS IN EXPERIMENTAL GINGIVITIS SUBJEC
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批准号:7625644
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项目类别:
-
资助金额:$2.55万
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财政年份:2006
-
负责人:Steven Offenbacher
-
依托单位:
MOTOR: MATERNAL ORAL THERAPY TO REDUCE OBSTETRIC RISK
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批准号:7377499
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项目类别:
-
资助金额:$21.04万
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财政年份:2005
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负责人:Steven Offenbacher
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依托单位:
CROSS-SECTIONAL STUDY OF CANDIDATE PREDICTOR BIOMARKERS IN HLTHY VS PERIOD SU
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批准号:7377565
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项目类别:
-
资助金额:$0.42万
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财政年份:2005
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负责人:Steven Offenbacher
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依托单位:
PERIODONTAL INTERVENTION FOR CARDIAC EVENTS - A PILOT STUDY
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批准号:7377443
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项目类别:
-
资助金额:$0.3万
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财政年份:2005
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负责人:Steven Offenbacher
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依托单位:
PERIODONTAL INTERVENTION FOR CARDIAC EVENTS - A PILOT STUDY
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批准号:7200246
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项目类别:
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资助金额:$5.43万
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财政年份:2004
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负责人:Steven Offenbacher
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依托单位:
EFFECTS OF PERIODONTAL THERAPY ON MARKERS OF ACUTE PHASE RESPONSE (APR) AND
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批准号:7200247
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项目类别:
-
资助金额:$5.03万
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财政年份:2004
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负责人:Steven Offenbacher
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依托单位:
THE EFFECTS OF PERIODONTAL THERAPY ON CARDIOVASCULAR FUNCTION-A PILOT STUDY
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批准号:7200227
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项目类别:
-
资助金额:$0.97万
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财政年份:2004
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负责人:Steven Offenbacher
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依托单位:
海外基金