CLINICAL TRIAL: EXPLORATORY PROTEOMIC ANALYSES OF GINGIVAL CREVICULAR FLUID IN H

临床试验：H 中龈沟液的探索性蛋白质组学分析

• 批准号: 7716896
• 负责人: Steven Offenbacher
• 金额: $ 1.16万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-02 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716896
• 关键词: Advertisements; Age; Biological Markers; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Daily; Dental Hygiene; Disease; Ensure; Exhibits; Funding; Gingival Crevicular Fluid; Gingivitis; Grant; Health; Hour; Hygiene; Institution; Liquid substance; Methods; Oral cavity; Participant; Periodontitis; Phase; Placement; Procedures; Prophylactic treatment; Proteomics; Purpose; Recruitment Activity; Research; Research Personnel; Resolution; Resources; Risk; Saliva; Source; Standards of Weights and Measures; Stents; Time; Tooth structure; United States National Institutes of Health; Visit; Week; healthy volunteer; scaling and root planing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Purpose: The overall purpose of this research is to identify biological markers for gum disease (gingivitis), which can be identified within the gum fluid (gingival crevicular fluid) or the saliva, that may be used to identify who is at greatest risk for developing gum disease and who responds best to treatments. Participants: Twenty-four to thirty participants, to ensure completion of twenty-four, will be recruited by advertisement. Participants will be between the ages of 18 & 65, will be in good general health and will exhibit naturally occurring (plaque-induced) gingivitis but no evidence of periodontitis. Procedures (methods): This study will involve induction of experimental gingivitis in healthy volunteers. Participants will be seen at the study center for twelve hours (8 visits) over a nine week time period. Following a one-week standard hygiene phase, participants will abstain from brushing and flossing teeth in one half of their mouths during a three week, no hygiene phase via placement of acrylic stents. Thereafter, participants will reinstate normal full mouth oral hygiene, daily plaque control and will be followed for four weeks during gingivitis resolution. Prophylaxis with scaling and root planing will be performed at exit as needed.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：这项研究的总体目的是确定牙龈疾病（牙龈炎）的生物标志物，这些标志物可以在牙龈液（龈沟液）或唾液中识别，可以用于识别谁是最有可能患牙龈疾病的人，以及谁对治疗反应最好。 参加者：24至30名参加者，以确保完成24，将通过广告招募。 参与者年龄在18 - 65岁之间，身体健康，表现出自然发生的（牙菌斑诱导的）牙龈炎，但没有牙周炎的证据。 程序（方法）：本研究将涉及在健康志愿者中诱导实验性牙龈炎。 受试者将在9周时间内在研究中心接受12小时（8次访视）的访视。 在为期一周的标准卫生阶段之后，参与者将在为期三周的无卫生阶段期间通过放置丙烯酸支架在其口腔的一半中放弃刷牙和使用牙线。 此后，参与者将恢复正常的全口口腔卫生，每日控制牙菌斑，并在牙龈炎消退期间随访四周。 根据需要，将在出口处进行刮治和根面平整的预防措施。