GENETICS OF ATOPIC DERMATITIS: ECZEMA HERPETICUM STUDY

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is being done to learn more about why atopic dermatitis patients get more viral skin infections such as Herpes simplex. When atopic dermatitis patients get disseminated skin outbreaks with herpes simplex virus, that condition is called eczema herpeticum (EH). Investigators are looking for the genes that increase the risk of having this condition. Changes in a gene can mean that some people may be more likely to have eczema herpeticum than others. The genes of patients who have eczema herpeticum will be compared to the genes of people who do not have this condition. Investigators have chosen to focus upon EH because it is felt to represent a reasonable, "real-life" surrogate for eczema vaccinatum (EV). EV is a severe and life threatening reaction to the smallpox vaccine.