ROLE OF BACTERIAL TOXINS IN ATOPIC DERMATITIS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 特应性皮炎是普通人群慢性皮肤炎的常见原因。众所周知，特应性皮炎可由细菌感染引发，某些被称为超抗原的细菌蛋白质有助于皮肤病的严重程度。目前这项研究的目的是调查为什么特应性皮炎患者容易受到细菌感染，以及金黄色葡萄球菌产生的超抗原是如何导致特应性皮炎患者皮肤炎症的。金黄色葡萄球菌是特应性皮炎患者皮肤上最常见的细菌。这项研究将从12岁以上的患者身上采集细菌培养、血液样本和皮肤活检。了解特应性皮炎中细菌感染的潜在机制可能会导致这种常见皮肤病的新疗法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Atopic dermatitis is a common cause of chronic skin inflammation in the general population. It is known that atopic dermatitis can be triggered by bacterial infection and that certain bacterial proteins called "superantigens" contribute to the severity of skin disease. The goal of the current study is to investigate why patients with atopic dermatitis are prone to bacterial infection and how superantigens produced by staphylococcus aureus, the most common bacteria found on the skin of patients with atopic dermatitis, contributes to skin inflammation in topic dermatitis. The study will involve taking bacterial cultures, blood samples and skin biopsies from patients over the age of 12 years old. An understanding of mechanisms underlying bacterial infection in atopic dermatitis is likely to lead to new treatments in this common skin disease.