ROLE OF ANTIMICROBIAL PEPTIDES IN HOST DEFENSE AGAINST VACCINIA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究包括对特应性皮炎、哮喘、牛皮癣患者和正常对照组的血细胞和皮肤进行分析，以确定特应性皮炎患者患牛痘湿疹的风险增加的原因。痘苗湿疹是一种严重威胁生命的皮疹，可由接种天花疫苗引起。它不会发生在牛皮癣、哮喘或正常对照患者中。因此，我们希望比较银屑病、哮喘或正常对照患者的血细胞和皮肤活检与特应性皮炎患者对天花疫苗的反应。血细胞和皮肤活检暴露在天花疫苗下将完全在实验室进行。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study involves an analysis of blood cells and skin from patients with atopic dermatitis, asthma, psoriasis, and normal controls to determine why patients with atopic dermatitis are at increased risk for developing eczema vaccinatum. Eczema vaccinatum is a severe life-threatening rash that can result from smallpox vaccination. It does not occur in patients with psoriasis, asthma, or normal controls. Thus, we wish to compare responses of blood cells and skin biopsies from patients with psoriasis, asthma, or normal controls to patients with atopic dermatitis to the smallpox vaccine. Exposure of blood cells and skin biopsies to smallpox vaccine will be done exclusively in the laboratory.