ROLE OF ANTIMICROBIAL PEPTIDES IN HOST DEFENSE AGAINST VACCINIA

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study involves an analysis of blood cells and skin from patients with atopic dermatitis, asthma, psoriasis, and normal controls to determine why patients with atopic dermatitis are at increased risk for developing eczema vaccinatum. Eczema vaccinatum is a severe life-threatening rash that can result from smallpox vaccination. It does not occur in patients with psoriasis, asthma, or normal controls. Thus, we wish to compare responses of blood cells and skin biopsies from patients with psoriasis, asthma, or normal controls to patients with atopic dermatitis to the smallpox vaccine. Exposure of blood cells and skin biopsies to smallpox vaccine will be done exclusively in the laboratory.