IMMUNOLOGIC MARKERS OF SEVERE REFRACTORY ATOPIC DERMATITIS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 每年在NJMRC，我们都会在日间项目中看到一部分患有严重特应性皮炎的成年患者，这些患者对大多数传统疗法都有抵抗力。 与他们的孩子不同，尽管进行了密集的补水治疗和局部药物治疗，他们的皮肤改善缓慢。 我们怀疑这些患者可能在皮肤的免疫防御方面存在明显的功能障碍，使他们更容易受到细菌和真菌感染，过敏原致敏的影响。这项研究将包括皮肤细菌培养，皮肤活检和血液样本。了解这些患者皮肤免疫系统的潜在差异可能会导致未来特应性皮炎的治疗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Every year at NJMRC we see a subset of adult patients in our Day Program with severe atopic dermatitis that is resistant to most traditional therapies. Unlike their child counterparts, improvement in their skin is slow despite intensive hydration therapy and topical medications. We suspect that these patients may have significant dysfunction in the immune defenses of their skin that makes them more susceptible to the effects of bacterial and fungal infection, allergen sensitization. This study will involve taking skin bacterial cultures, skin biopsies and blood samples. An understanding of the underlying differences in the immune system of the skin in these patients may lead to future treatments for atopic dermatitis.