ADVN BIOMARKER STUDY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 由美国国立卫生研究院资助的特应性皮炎和牛痘网络（ADVN）由一组学术医疗中心组成，这些中心将进行临床研究，其总体目标是使天花疫苗对数百万特应性皮炎（AD）患者更安全。 患有AD或已超过AD的人经常会受到皮肤感染。这些疾病包括疱疹、传染性软疣和牛痘性湿疹等病毒感染。 牛痘疹是一种严重的，有时是致命的皮肤感染引起的接触天花疫苗。 在1972年之前，美国人常规接种这种疫苗，但由于这种疾病（天花）已经得到控制，疫苗接种不再作为儿童常规护理的一部分。 然而，现在，由生物恐怖主义行为引起的天花流行病可能使天花疫苗成为必要。 ADVN的使命是了解为什么患有AD或过去患有AD的患者容易增加皮肤感染，并找到更安全的方法来保护他们及其家人免受天花的可能性。 ADVN生物标志物登记研究只是ADVN正在进行的研究之一。 本研究的主要目的是收集湿疹、疱疹性湿疹、牛痘性湿疹、湿疹伴传染性软疣、传染性软疣受试者以及正常健康受试者的信息。登记/生物标志物研究的另一个目的是评估各种生物标志物与受试者特征之间的关系。 将在5个不同的医疗中心从约1,000名研究志愿者中采集血液样本。 ADVN研究人员计划每年从所有中心研究至少185份血液样本。 国家犹太医学和研究中心将入组约200例受试者（每年50例）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Atopic Dermatitis and Vaccinia Network (ADVN), funded by the National Institutes of Health, consists of a group of academic medical centers that will perform clinical research studies with the overall goal to make smallpox vaccines safer for the millions of people with atopic dermatitis (AD). People who have AD or who have outgrown AD often get skin infections. These can include such viral infections as herpes, molluscum contagiosum and eczema vaccinatum. Eczema vaccinatum is a severe and sometimes fatal skin infection caused by exposure to smallpox vaccine. Before 1972 people in the US were routinely given this vaccine but because this disease (smallpox) has been controlled, vaccinations are no longer given as part of routine care of children. Now, however, an epidemic of smallpox caused by a bioterrorist act could make smallpox vaccinations necessary. The mission of the ADVN is to understand why patients who have AD, or who have had it in the past, are prone to increased skin infections and to find safer ways to protect them and their families from the possibility of smallpox. The ADVN Biomarker Registry Study is just one of the studies being done by the ADVN. The Primary Objective of this study is collecting information about subjects who have eczema, eczema herpeticum, eczema vaccinatum, eczema with molluscum contagiosum, molluscum contagiosum, and normal, healthy subjects. Another objective of the Registry/Biomarkers study is to assess the relationship between various biomarkers and subject characteristics. Blood samples will be taken from about 1,000 study volunteers at 5 different medical centers. ADVN investigators plan to study at least 185 blood samples each year from all centers. National Jewish Medical and Research Center will enroll approximately 200 subjects (50 per year).