EFFECT OF ETS EXPOSURE ON STEROID RESPONSIVENESS AMONG CHILDREN WITH ASTHMA

ETS 暴露对哮喘儿童类固醇反应的影响

• 批准号: 7719401
• 负责人: Mary D. Klinnert
• 金额: $ 0.01万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719401
• 关键词: Adrenal Cortex Hormones; Adult; Age; Area; Asthma; Blood; Blood Cells; Breathing; Caring; Cells; Child; Cigarette Smoker; Clinical; Computer Retrieval of Information on Scientific Projects Database; Effectiveness; Evaluation; Exposure to; Funding; Grant; Home environment; Infant; Inflammation; Institution; Laboratories; Low income; Lung; Morbidity - disease rate; Oral; Pharmaceutical Preparations; Prednisone; Reporting; Research; Research Personnel; Resources; Schools; Smoker; Smoking; Source; Steroids; Symptoms; Testing; Tobacco smoke; United States National Institutes of Health; Week; base; cigarette smoking; non-smoker; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Children with asthma who are exposed to cigarette smoke have higher morbidity levels than those of children not exposed. Corticosteroids, either oral or inhaled, are among the most effective medications for asthma because they decrease inflammation that underlies asthma symptoms. A recent study showed that children who were given thier inhaled steroids at school showed improvements compared to children with usual care; however, the improvement occurred only among the children not exposed to cigarette smoke at home. Among adults with asthma, cigarette smokers do not respond to oral steroids as well as non-smokers, and and studies of cells show the ways in which the cells of smokers are not responsive to steroids. In this study we will test the effectiveness of steroids among low-income children who participated in a study since they were infants and who were found at age 7 to have asthma. We hypothesize that children with asthma who area exposed to cigarette smoke will respond more poorly to a course of oral steroids than will the non-exposed children, and that their clinical responsiveness will be reflected in tests done on their blood cells. The children will come in to the laboratory where symptom reports and lung testing will be used to determine whether their asthma is being poorly controlled, thier blood will be drawn, and their exposure to cigarette smoke will be evaluated. Those whoare in poor control will receive prednisone (an oral steroid) for one week. They will return for an evaluation based on lung testing and symptom report to determine their clinical response to the prednisone. Their blood will be tested to see if the steroid response pattens identified among smoking with adults with asthma is similar among children with asthma who are exposed to secondhand tobacco smoke.

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 暴露于香烟烟雾中的哮喘儿童的发病率高于未暴露于香烟烟雾中的儿童。皮质类固醇，无论是口服还是吸入，都是治疗哮喘最有效的药物之一，因为它们可以减少哮喘症状的炎症。 最近的一项研究表明，在学校接受吸入性类固醇的儿童与接受常规护理的儿童相比表现出改善;然而，这种改善仅发生在家中未暴露于香烟烟雾的儿童中。 在成年哮喘患者中，吸烟者对口服类固醇的反应不如不吸烟者，细胞研究显示吸烟者的细胞对类固醇没有反应。 在这项研究中，我们将测试类固醇在低收入儿童中的有效性，这些儿童从婴儿开始就参加了一项研究，并在7岁时被发现患有哮喘。 我们假设，与未暴露于香烟烟雾的儿童相比，暴露于香烟烟雾的哮喘儿童对口服类固醇的反应更差，并且他们的临床反应将反映在对他们的血细胞进行的测试中。 这些孩子将进入实验室，在那里症状报告和肺部测试将被用来确定他们的哮喘是否控制不良，他们的血液将被抽取，他们暴露于香烟烟雾将被评估。那些控制不好的人将接受一周的强的松（一种口服类固醇）治疗。 他们将返回进行基于肺部测试和症状报告的评估，以确定他们对泼尼松的临床反应。 他们的血液将被检测，以确定吸烟的成人哮喘患者的类固醇反应模式是否与接触二手烟草烟雾的哮喘儿童相似。