LIBMAN-SACKS ENDOCARDITIS AND NEUROPSYCHIATRIC SYSTEMIC LUPUS ERTHENMATOSUS

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 本研究的目的是： 1) 横断面确定 SLE 受试者中 TEE 检测到的瓣膜赘生物对活动性脑微栓塞、灌注改变、缺血性脑损伤和 NPSLE 存在的影响。 SLE 患者的研究结果将与对照组的研究结果进行比较。 2) 纵向确定新发或复发 NPSLE 患者以及缓解期间与无 NPSLE 患者或匹配对照的基线数据相比，瓣膜赘生物、活动性脑微栓塞和异常脑灌注是否改善或正常化。 3) 横断面确定 SLE 受试者中活动性脑微栓塞、脑灌注改变、脑损伤和 NPSLE 与其他瓣膜异常（例如瓣膜增厚或瓣膜反流）的存在，除了瓣膜赘生物之外或独立于瓣膜赘生物；并纵向确定 NPSLE 患者的这些关系。 SLE 患者的研究结果将与没有 NPSLE 的患者或匹配对照的基线数据进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is: 1) To determine cross-sectionally in SLE subjects the effects of valve vegetations detected by TEE on the presence of active cerebral microemboli, altered perfusion, ischemic brain lesions, and NPSLE. Findings in SLE patients will be compared to those in controls. 2) To determine longitudinally in patients with new or recurrent NPSLE and during remission whether valve vegetations, active cerebral microemboli, and abnormal cerebral perfusion improve, or normalize when compared to baseline data in patients without NPSLE or matched controls. 3) To determine cross-sectionally in SLE subjects the presence of active cerebral microemboli, altered brain perfusion, brain injury, and NPSLE in relation to other valve abnormalities, such as valve thickening or valve regurgitation, in addition to or independently of valve vegetations; and to determine longitudinally these relationships in patients with NPSLE. Findings in SLE patients will be compared to baseline data in patients without NPSLE or matched controls.