LIBMAN-SACKS ENDOCARDITIS AND NEUROPSYCHIATRIC SYSTEMIC LUPUS ERTHENMATOSUS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的目的是： 1)在SLE受试者中横断面确定TEE检测到的瓣膜赘生物对活动性脑微栓子、血流灌注改变、缺血性脑损害和NPSLE的影响。系统性红斑狼疮患者的研究结果将与对照组进行比较。 2)纵向研究新发或复发NPSLE患者及缓解期NPSLE患者的瓣膜赘生物、活动性脑微栓子和异常脑血流灌注，与非NPSLE患者或匹配对照组的基线数据相比，是否改善或恢复正常。 3)确定SLE受试者是否存在活动性脑微栓子、脑血流灌注改变、脑损伤和NPSLE与其他瓣膜异常的相关性，如瓣膜增厚或瓣膜返流，以及与瓣膜赘生物有关的情况；并纵向确定NPSLE患者的这些关系。SLE患者的发现将与非NPSLE患者或匹配的对照组的基线数据进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is: 1) To determine cross-sectionally in SLE subjects the effects of valve vegetations detected by TEE on the presence of active cerebral microemboli, altered perfusion, ischemic brain lesions, and NPSLE. Findings in SLE patients will be compared to those in controls. 2) To determine longitudinally in patients with new or recurrent NPSLE and during remission whether valve vegetations, active cerebral microemboli, and abnormal cerebral perfusion improve, or normalize when compared to baseline data in patients without NPSLE or matched controls. 3) To determine cross-sectionally in SLE subjects the presence of active cerebral microemboli, altered brain perfusion, brain injury, and NPSLE in relation to other valve abnormalities, such as valve thickening or valve regurgitation, in addition to or independently of valve vegetations; and to determine longitudinally these relationships in patients with NPSLE. Findings in SLE patients will be compared to baseline data in patients without NPSLE or matched controls.