LIBMAN-SACKS ENDOCARDITIS AND NEUROPSYCHIATRIC SYSTEMIC LUPUS ERTHENMATOSUS

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 本研究的目的是： 1)确定SLE受试者的横截面TEE检测到的瓣膜赘生物对活动性脑微栓子、灌注改变、缺血性脑病变和NPSLE的影响。SLE患者的结果将与对照组进行比较。 2)纵向确定新发或复发性NPSLE患者和缓解期患者的瓣膜赘生物、活动性脑微栓子和异常脑灌注与无NPSLE患者或匹配对照的基线数据相比是否改善或正常化。 3)确定SLE受试者中活动性脑微栓子、脑灌注改变、脑损伤和NPSLE与其他瓣膜异常（如瓣膜增厚或瓣膜返流）的关系（除瓣膜赘生物外或与瓣膜赘生物无关）;并确定NPSLE患者中这些关系的纵向变化。 将SLE患者的结果与无NPSLE患者或匹配对照的基线数据进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is: 1) To determine cross-sectionally in SLE subjects the effects of valve vegetations detected by TEE on the presence of active cerebral microemboli, altered perfusion, ischemic brain lesions, and NPSLE. Findings in SLE patients will be compared to those in controls. 2) To determine longitudinally in patients with new or recurrent NPSLE and during remission whether valve vegetations, active cerebral microemboli, and abnormal cerebral perfusion improve, or normalize when compared to baseline data in patients without NPSLE or matched controls. 3) To determine cross-sectionally in SLE subjects the presence of active cerebral microemboli, altered brain perfusion, brain injury, and NPSLE in relation to other valve abnormalities, such as valve thickening or valve regurgitation, in addition to or independently of valve vegetations; and to determine longitudinally these relationships in patients with NPSLE. Findings in SLE patients will be compared to baseline data in patients without NPSLE or matched controls.