ORAL CONTRACEPTIVES IN METABOLIC SYNDROME

代谢综合征中的口服避孕药

• 批准号: 7717032
• 负责人: KAI I CHEANG
• 金额: $ 3.22万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717032
• 关键词: Affect; Cardiovascular Diseases; Cardiovascular system; Computer Retrieval of Information on Scientific Projects Database; Contraceptive Agents; Data; Diabetes Mellitus; Ethinyl Estradiol; Event; Funding; Goals; Grant; Individual; Inflammatory; Institution; Insulin Resistance; Ischemic Stroke; Link; Low Dose Oral Contraceptives; Metabolic syndrome; Methods; Myocardial Infarction; Oral Contraceptives; Patients; Research; Research Personnel; Resources; Risk; Risk Factors; Safety; Source; Syndrome; Thrombophilia; Tobacco use; United States National Institutes of Health; Woman; birth control; cardiovascular disorder risk; cardiovascular risk factor; expectation; hypercholesterolemia; innovation; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Oral contraceptives (OCs) are the most widely used method of reversible birth control. However, the long-term cardiovascular safety of the widely used low-dose OCs (ethinyl-estradiol 50 g) is still debated. Although cardiovascular events are rare in young women whether they use OCs or not, the risks of myocardial infarction and ischemic stroke are increased among users of OCs who have conventional cardiovascular risk factors such as use of tobacco, diabetes or hypercholesterolemia. However, the risk of cardiovascular events in OC users with emerging cardiovascular risk factors have not been investigated. One such emerging cardiovascular risk factor is the metabolic syndrome. Recently, the metabolic syndrome has been linked with the risk of cardiovascular disease. The syndrome is a clustering of risk factors in a single individual, and its underlying cause may be insulin resistance. The investigator's long-term goal is to understand the best way to prevent and treat cardiovascular disease in women. The objective of this particular application is to obtain pilot data on the extent to which the metabolic syndrome affects cardiovascular risks in women taking OCs. We hypothesize that the metabolic syndrome predicts higher cardiovascular risks in OC users. Results of this study will clarify the risk factors for cardiovascular events in women taking OCs, and will serve as pilot data for an NIH proposal. Once the cardiovascular risk factors of OC users are understood, clinicians can make better informed decisions about contraceptive choices in their patients. The proposed research is innovative, because the effects of the metabolic syndrome on cardiovascular risk factors in OC users have not been previously studied. At the completion of these studies, our expectation is that use of OCs worsens insulin resistance, hypercoagulability and inflammatory markers in women with the metabolic syndrome. Collectively, the results of these studies will clarify the proper candidates for OCs, so that the appropriate use of OCs with the least harm will be possible.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 口服避孕药（OC）是最广泛使用的可逆避孕方法。然而，广泛使用的低剂量OC（炔雌醇50 g）的长期心血管安全性仍存在争议。 尽管无论是否使用口服避孕药，年轻女性的心血管事件都很少见，但在有传统心血管危险因素（如吸烟、糖尿病或高胆固醇血症）的口服避孕药使用者中，心肌梗死和缺血性卒中的风险增加。 然而，尚未研究具有新兴心血管危险因素的OC使用者的心血管事件风险。 代谢综合征是一种新出现的心血管危险因素。 最近，代谢综合征与心血管疾病的风险有关。 该综合征是单个个体的风险因素的聚集，其根本原因可能是胰岛素抵抗。 研究者的长期目标是了解预防和治疗女性心血管疾病的最佳方法。 这项特殊应用的目的是获得关于代谢综合征影响服用口服避孕药妇女心血管风险程度的试验数据。 我们假设代谢综合征预示着OC使用者的心血管风险较高。 这项研究的结果将阐明服用口服避孕药的妇女发生心血管事件的危险因素，并将作为NIH提案的试点数据。 一旦了解了OC使用者的心血管风险因素，临床医生就可以对患者的避孕选择做出更明智的决定。 这项研究是创新的，因为代谢综合征对OC使用者心血管危险因素的影响以前没有研究过。 在这些研究完成后，我们的期望是，使用OC的胰岛素抵抗，高凝状态和炎症标志物的妇女代谢综合征。 总的来说，这些研究的结果将澄清业主立案法团的适当候选人，以便能够以最小的伤害适当使用业主立案法团。