WHITE BLOOD CELLS, EXERCISE, AND CHILDREN: INITIAL MECHANISMS

白细胞、运动和儿童：初始机制

• 批准号: 7725002
• 负责人: DAN M COOPER
• 金额: $ 0.18万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7725002
• 关键词: Acoustics; Air; Anthropometry; Biolectric Impedance; Body Composition; Child; Computer Retrieval of Information on Scientific Projects Database; Development; Dual-Energy X-Ray Absorptiometry; Electric Conductivity; Energy Metabolism; Exercise; Fatty acid glycerol esters; Funding; Grant; Growth; Human; Institution; Intervention; Leukocytes; Life; Magnetic Resonance Imaging; Measurement; Neonatal; Newborn Infant; Perinatal; Plethysmography; Potassium; Premature Infant; Process; Research; Research Personnel; Resources; Skeletal Muscle; Source; Spectrum Analysis; Techniques; Time; Tissues; Tracer; Ultrasonography; United States National Institutes of Health; indexing; insight

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Understanding the dynamic changes in body composition in the perinatal and early neonatal period has been a major of focus of neonatal research for over a century. At no time in the life of humans is energy expenditure for growth so large and the process of new tissue development so rapid. Measurements of body composition and energy expenditure are essential if we are to gain insights into the mechanisms of how interventions like assisted exercise influence body composition in premature babies. For many reasons involving technical, ethical, and feasibility factors, making accurate measurements of both body composition and energy expenditure has remained a singular challenge in this field (1), and the armamentarium available for these important indexes of growth are limited in the context of the newborn. Current techniques include: anthropometry, total body electrical conductance, tracer dilution, total body potassium, bioelectrical impedance, magnetic resonance imaging and spectroscopy, acoustic plethysmography, air displacement, Dual Energy X-ray Absorptiometry (DEXA), Quantitative ultrasound (QUS), and regional ultrasonography of skeletal muscle and fat mass (2-8).

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 一个多世纪以来，了解围产期和新生儿早期身体成分的动态变化一直是新生儿研究的重点。 在人类一生中，生长所需的能量消耗从未如此之大，新组织的发育过程也从未如此迅速。 如果我们要深入了解辅助运动等干预措施如何影响早产儿身体成分的机制，那么身体成分和能量消耗的测量至关重要。 由于涉及技术、伦理和可行性因素的多种原因，准确测量身体成分和能量消耗仍然是该领域的一个独特挑战 (1)，并且可用于这些重要生长指标的设备在新生儿的背景下是有限的。 目前的技术包括：人体测量学、全身电导、示踪剂稀释、全身钾、生物电阻抗、磁共振成像和光谱学、声体积描记法、空气置换、双能 X 射线吸收测定法 (DEXA)、定量超声 (QUS) 以及骨骼肌和脂肪量的区域超声检查 (2-8)。