WHITE BLOOD CELLS, EXERCISE, AND CHILDREN: INITIAL MECHANISMS

点击翻译按钮获取中文摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Understanding the dynamic changes in body composition in the perinatal and early neonatal period has been a major of focus of neonatal research for over a century. At no time in the life of humans is energy expenditure for growth so large and the process of new tissue development so rapid. Measurements of body composition and energy expenditure are essential if we are to gain insights into the mechanisms of how interventions like assisted exercise influence body composition in premature babies. For many reasons involving technical, ethical, and feasibility factors, making accurate measurements of both body composition and energy expenditure has remained a singular challenge in this field (1), and the armamentarium available for these important indexes of growth are limited in the context of the newborn. Current techniques include: anthropometry, total body electrical conductance, tracer dilution, total body potassium, bioelectrical impedance, magnetic resonance imaging and spectroscopy, acoustic plethysmography, air displacement, Dual Energy X-ray Absorptiometry (DEXA), Quantitative ultrasound (QUS), and regional ultrasonography of skeletal muscle and fat mass (2-8).