BETA-CELL FAILURE IN OBESE AFRICAN-AMERICANS WITH HYPERGLYCEMIC CRISIS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will test the hypothesis that obese African Americans with diabetic ketoacidosis are susceptible to B-cell dysfunction due to sustained elevations of plasma glucose (glucose toxicity) and/or free fatty acid levels (lipotoxicity).