BETA-CELL FAILURE IN OBESE AFRICAN-AMERICANS WITH HYPERGLYCEMIC CRISIS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究将验证糖尿病酮症酸中毒的肥胖非裔美国人由于持续升高的血浆葡萄糖（葡萄糖毒性）和/或游离脂肪酸水平（脂肪毒性）而易患b细胞功能障碍的假设。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will test the hypothesis that obese African Americans with diabetic ketoacidosis are susceptible to B-cell dysfunction due to sustained elevations of plasma glucose (glucose toxicity) and/or free fatty acid levels (lipotoxicity).