BETA-CELL FAILURE IN OBESE AFRICAN-AMERICANS WITH HYPERGLYCEMIC CRISIS

患有高血糖危机的肥胖非洲裔美国人的 β 细胞衰竭

• 批准号: 7376368
• 负责人: Guillermo E Umpierrez
• 金额: $ 2.8万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376368
• 关键词: BETA; CELL; FAILURE; OBESE; AFRICAN

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will test the hypothesis that obese African Americans with diabetic ketoacidosis are susceptible to B-cell dysfunction due to sustained elevations of plasma glucose (glucose toxicity) and/or free fatty acid levels (lipotoxicity).

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究将检验这样一种假设，即患有糖尿病酮症酸中毒的肥胖非裔美国人容易由于血糖(葡萄糖毒性)和/或游离脂肪酸水平(脂毒性)持续升高而导致B细胞功能障碍。