TRANSITIONS: INSULIN RESISTANCE AND DECLINING PHYSICAL ACTIVITY LEVELS IN AFR

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目的目标是确定非洲裔美国人和拉美裔女孩青春期体力活动减少的生理和心理相关性。对女孩青春期体力活动减少的解释机制尚未得到很好的理解，阻碍了在这一关键时期制定有效的健康促进干预措施的能力。然而，这一现象在人类研究中的性别、种族和国籍以及动物研究中的跨物种中都得到了一致的发现，这表明它可能有生物学基础。非洲裔美国人和拉美裔女孩的青春期转变代表了一个发育的“关键时期”，在这个时期，胰岛素抵抗增加，体力活动减少。在这些易感人群中，这些“危险的”代谢和行为变化可能在一定程度上解释了他们患肥胖症、2型糖尿病和代谢综合征风险增加的原因。100名女孩(50名拉丁裔和50名非裔美国人)将从坦纳阶段1-坦纳阶段3进行跟踪。这项研究将包括每年对GRCR的过夜访问以及季度加速计和问卷研究。这项研究的总体假设是，青春期胰岛素抵抗与(下游)身体活动的代谢和情感决定因素有关，包括情绪和能量水平，这些代谢和心理变化导致青春期体力活动显著下降。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is to detemine physiological and pyschological correlates of the decline in physical activity in African American and Latina girls during puberty. The mechanism explaining the well known decline in physical activity that occurs in girls during adolescence is not well understood and hinders the ability to establish effective health promotion interventions during this critical period. However, the fact that this phenomenon has been found consistently across gender, ethnicity and nationality in human studies, and across species in animal studies, suggests it may have a biological basis. The pubertal transtion in African American and Latina girls represents a "critical period" of development in which increased insulin resistance and decreased physical activity have been noted. These "risky" metabolic and behavioral changes in these susceptible groups may explain, in part, their increased risk for obesity, type 2 diabetes and the metabolic syndrome. 100 girls (50 Latina and 50 African American) girls will be followed from Tanner Stage 1 - Tanner Stage 3+. The research will include yearly overnight visits to the GRCR and quarterly accelerometry and questionnaire studies. The overall hypotheses of this study are that pubertal insulin resistance is linked to (downstream) metabolic and affective determinants of physical activity including mood and enery levels, and that these metabolic and psychological changes contribute to the marked decline in physical activity that occurs during puberty.