TRANSITIONS: INSULIN RESISTANCE AND DECLINING PHYSICAL ACTIVITY LEVELS IN AFR

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 这个项目的目标是确定非裔美国人和拉丁美洲女孩青春期身体活动减少的生理和心理相关性。 众所周知，女孩在青春期的身体活动减少，其原因尚不清楚，妨碍了在这一关键时期采取有效的健康促进干预措施。 然而，在人类研究中，这种现象在不同性别、种族和国籍之间，以及在动物研究中，这种现象在不同物种之间都是一致的，这表明它可能有生物学基础。 非洲裔美国人和拉丁裔女孩的青春期过渡代表了发展的“关键时期”，其中胰岛素抵抗增加和体力活动减少。 这些易受影响人群中的这些“危险”代谢和行为变化可能部分解释了他们患肥胖症、2型糖尿病和代谢综合征的风险增加。 100名女孩（50名拉丁裔和50名非洲裔美国人）将从坦纳阶段1 -坦纳阶段3+。 这项研究将包括每年对GRCR进行一次通宵访问，每季度进行一次加速度测量和问卷调查。 这项研究的总体假设是青春期胰岛素抵抗与身体活动的（下游）代谢和情感决定因素有关，包括情绪和能量水平，这些代谢和心理变化导致青春期身体活动显著下降。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is to detemine physiological and pyschological correlates of the decline in physical activity in African American and Latina girls during puberty. The mechanism explaining the well known decline in physical activity that occurs in girls during adolescence is not well understood and hinders the ability to establish effective health promotion interventions during this critical period. However, the fact that this phenomenon has been found consistently across gender, ethnicity and nationality in human studies, and across species in animal studies, suggests it may have a biological basis. The pubertal transtion in African American and Latina girls represents a "critical period" of development in which increased insulin resistance and decreased physical activity have been noted. These "risky" metabolic and behavioral changes in these susceptible groups may explain, in part, their increased risk for obesity, type 2 diabetes and the metabolic syndrome. 100 girls (50 Latina and 50 African American) girls will be followed from Tanner Stage 1 - Tanner Stage 3+. The research will include yearly overnight visits to the GRCR and quarterly accelerometry and questionnaire studies. The overall hypotheses of this study are that pubertal insulin resistance is linked to (downstream) metabolic and affective determinants of physical activity including mood and enery levels, and that these metabolic and psychological changes contribute to the marked decline in physical activity that occurs during puberty.