Anesthesiology & Perioperative Medicine Research Training

描述（由申请人提供）：本提案的目标是在与麻醉学和围手术期医学相关的生物医学前沿（和新兴）领域提供深入的研究培训，包括重症监护。华盛顿大学麻醉科在学术卓越和临床创新方面有着悠久的历史。这个新的程序应用程序旨在恢复在麻醉学（35年的历史）运行时间最长的培训计划之一。经过十年的空间限制，华盛顿大学正在以重要的方式重建学术麻醉学，完成研究空间承诺（总计24,000平方英尺）和所需资源，以增加5-6名资金充足的中高级医师科学家和研究科学家教师。该提案旨在利用这些新的部门倡议，更重要的是，利用西澳大学现有的优秀研究环境，以培养下一代麻醉内科科学家。受训人员将从全国候选人中选拔。该计划的结构包括2-3年的研究培训，由美国国立卫生研究院资助的华盛顿大学教师导师密切监督，项目范围从实验室科学到更多的转化和临床项目；每年将招收3-4名完成麻醉学住院医师和相关临床专科培训的新研究员（因此研究员将在医学博士后5-6年）。重点介绍围手术期医学相关的五大研究领域。这些学科包括（按字母顺序排列）：1)心血管-肺生物学与再生医学，2)临床结果研究与流行病学，3)基因组科学与生物信息学，4)神经科学，5)药理学。该计划的目标包括获得基本研究技能，掌握相关文献，了解负责任的研究行为，包括IRB/IACUC的批准，以手稿形式总结研究成果和资助申请的能力，以及在诸如期刊俱乐部和国家科学会议等公共环境中展示研究成果。培训生的进步由个别的研究员审查委员会定期监测（第一年每季度与导师和研究员会面，之后每半年一次），并将总结结果报告给负责接受/雇用研究员并跟踪其进展的部门培训补助金执行委员会。此外，威斯康星大学外部科学监督委员会每年召开一次会议，就培训计划的各个方面向执行委员会提供建议。该项目的总体目的是培养下一代围手术期医师、科学家和学者。

DESCRIPTION (provided by applicant): The objective of this proposal is to provide in-depth research training in cutting edge (and emerging) areas of biomedical science related to anesthesiology and perioperative medicine, including critical care. The University of Washington (UW) Department of Anesthesiology has a long history of academic excellence and clinical innovation. This new program application aims to reinstate one of the longest running training programs in anesthesiology (35 year history). After a decade of space constraints, UW is rebuilding academic anesthesiology in significant ways, complete with research space commitments (total 24,000 square feet) and resources required to add 5-6 well funded mid- senior level physician-scientist and research scientist faculty. This proposal is designed to capitalize on these new departmental initiatives and, importantly, the existing outstanding research environment at UW in order to train the next generation of anesthesiology physician scientists. Trainees will be sought from a national pool of candidates. The structure of this program involves 2-3 years of research training closely supervised by NIH-funded UW faculty mentors on projects ranging from laboratory-based science to more translational and clinical projects; 3-4 new fellows will be enrolled each year who have completed anesthesiology residencies and relevant clinical subspecialty training (so fellows will be 5-6 years post-MD). Five major research areas relevant to perioperative medicine are emphasized. These include (alphabetically): 1) cardiovascular-pulmonary biology & regenerative medicine, 2) clinical outcomes research & epidemiology, 3) genome sciences & bioinformatics, 4) neurosciences, and 5) pharmacology. Goals of the program include acquisition of fundamental research skills, mastery of the relevant literature, understanding responsible conduct of research including IRB/IACUC approvals, ability to summarize research findings in manuscript form and grant applications, and presenting findings in public settings such as journal clubs and national scientific meetings. Trainee progress is monitored regularly by an individualized fellow-specific review committee (meeting with mentor and fellow quarterly in year 1, semi-annually thereafter) with summary findings reported to the departmental training grant executive committee responsible for accepting/hiring fellows and following their progress. In addition, a UW-wide external scientific oversight board meets yearly to offer advice to the executive committee on all aspects of the training program. The overall intent of the program is to develop the next generation of perioperative physician scientists and academicians. Relevance: During surgery and critical illness, patients reproducibly experience stress to the limits of human physiology; this is a unique period where human tissue samples can be obtained ethically as well. Mechanistic basic science, translational, and clinical studies targeting perioperative physiology provide important insights broadly relevant across medicine, a fact recently appreciated by many medical specialties. With the aging population, developing physician scientists capable of tackling scientific questions in this important arena of medicine should make care of surgery, trauma, and intensive care patients safer.