Anesthesiology & Perioperative Medicine Research Training

描述(由申请人提供)：这项建议的目标是在与麻醉学和围手术期医学相关的生物医学前沿(和新兴领域)提供深入的研究培训，包括危重护理。华盛顿大学麻醉学系在学术和临床创新方面有着悠久的历史。这一新的计划应用程序旨在恢复麻醉学(35年历史)中最长的跑步训练计划之一。在经历了十年的空间限制之后，华盛顿大学正在以重大的方式重建学术麻醉学，完成了研究空间承诺(总计24,000平方英尺)和所需资源，以增加5-6名资金充足的中高级医生-科学家和研究科学家教职员工。这项建议旨在利用这些新的部门倡议，更重要的是，利用威斯康星大学现有的优秀研究环境，以培养下一代麻醉学内科科学家。受训人员将从全国候选人库中挑选。这一计划的结构包括2-3年的研究培训，由NIH资助的华盛顿大学教师导师密切监督的项目，从以实验室为基础的科学，更多的翻译和临床项目；每年将招收3-4名完成麻醉学住院医师和相关临床专科培训的新研究员(因此，研究员将在医学博士学位毕业后5-6年)。重点介绍了与围手术期医学相关的五个主要研究领域。这些学科包括(按字母顺序)：1)心血管-肺生物学和再生医学，2)临床结果研究和流行病学，3)基因组科学和生物信息学，4)神经科学，5)药理学。该计划的目标包括获得基本研究技能，掌握相关文献，了解负责任的研究行为，包括IRB/IACUC批准，能够以手稿形式总结研究结果和拨款申请，以及在公开场合展示研究结果，如期刊俱乐部和国家科学会议。一个专门针对学员的个别审查委员会定期监测学员的进展情况(第一年每季度与导师和学员举行一次会议，此后每半年举行一次会议)，并向负责接收/聘用学员的部门培训补助金执行委员会报告摘要结果，并跟踪他们的进展情况。此外，华盛顿大学范围内的外部科学监督委员会每年召开会议，就培训计划的所有方面向执行委员会提供建议。该计划的总体目的是培养下一代围手术期内科医生、科学家和院士。 相关性：在手术和危重疾病期间，患者会重复地经历人类生理极限的压力；这是一个独特的时期，也可以从伦理上获得人类组织样本。以围手术期生理学为目标的机械学基础科学、翻译和临床研究提供了与医学广泛相关的重要见解，这一事实最近被许多医学专业所认可。随着人口老龄化，能够在这个重要的医学领域解决科学问题的发展中的内科科学家应该会使手术、创伤和重症监护患者的护理更加安全。

DESCRIPTION (provided by applicant): The objective of this proposal is to provide in-depth research training in cutting edge (and emerging) areas of biomedical science related to anesthesiology and perioperative medicine, including critical care. The University of Washington (UW) Department of Anesthesiology has a long history of academic excellence and clinical innovation. This new program application aims to reinstate one of the longest running training programs in anesthesiology (35 year history). After a decade of space constraints, UW is rebuilding academic anesthesiology in significant ways, complete with research space commitments (total 24,000 square feet) and resources required to add 5-6 well funded mid- senior level physician-scientist and research scientist faculty. This proposal is designed to capitalize on these new departmental initiatives and, importantly, the existing outstanding research environment at UW in order to train the next generation of anesthesiology physician scientists. Trainees will be sought from a national pool of candidates. The structure of this program involves 2-3 years of research training closely supervised by NIH-funded UW faculty mentors on projects ranging from laboratory-based science to more translational and clinical projects; 3-4 new fellows will be enrolled each year who have completed anesthesiology residencies and relevant clinical subspecialty training (so fellows will be 5-6 years post-MD). Five major research areas relevant to perioperative medicine are emphasized. These include (alphabetically): 1) cardiovascular-pulmonary biology & regenerative medicine, 2) clinical outcomes research & epidemiology, 3) genome sciences & bioinformatics, 4) neurosciences, and 5) pharmacology. Goals of the program include acquisition of fundamental research skills, mastery of the relevant literature, understanding responsible conduct of research including IRB/IACUC approvals, ability to summarize research findings in manuscript form and grant applications, and presenting findings in public settings such as journal clubs and national scientific meetings. Trainee progress is monitored regularly by an individualized fellow-specific review committee (meeting with mentor and fellow quarterly in year 1, semi-annually thereafter) with summary findings reported to the departmental training grant executive committee responsible for accepting/hiring fellows and following their progress. In addition, a UW-wide external scientific oversight board meets yearly to offer advice to the executive committee on all aspects of the training program. The overall intent of the program is to develop the next generation of perioperative physician scientists and academicians. Relevance: During surgery and critical illness, patients reproducibly experience stress to the limits of human physiology; this is a unique period where human tissue samples can be obtained ethically as well. Mechanistic basic science, translational, and clinical studies targeting perioperative physiology provide important insights broadly relevant across medicine, a fact recently appreciated by many medical specialties. With the aging population, developing physician scientists capable of tackling scientific questions in this important arena of medicine should make care of surgery, trauma, and intensive care patients safer.