Anesthesiology & Perioperative Medicine Research Training

这项建议的目的是提供深入的研究培训的前沿（和合并）领域， 与麻醉学和围手术期医学相关的生物医学科学，包括重症监护。的 华盛顿大学（UW）麻醉学系具有悠久的学术历史， 临床创新这个新的程序应用程序的目的是恢复一个最长的运行训练 麻醉学课程（35年历史）。经过十年的空间限制，华盛顿大学正在重建 学术麻醉学的重要方式，完成研究空间的承诺（共24000 平方英尺）和增加5-6个资金充足的中高级医生-科学家和研究所需的资源 科学家学院。本提案旨在利用这些新的部门举措， 重要的是，现有的优秀的研究环境在华盛顿大学，以培养下一代的 麻醉学科学家将从国家候选人库中挑选受训人员。的 该计划的结构包括由NIH资助的UW密切监督的2-3年的研究培训 教师导师的项目范围从实验室为基础的科学更多的转化和临床项目; 3-4每年将招收新的研究员，他们已经完成了麻醉学住院医师和相关的 临床专科培训（因此研究员将在医学博士后5-6年）。五个主要研究领域， 强调围手术期医学。这些包括（病理学上）：1）心血管-肺动脉 生物学和再生医学，2）临床结果研究和流行病学，3）基因组科学和 生物信息学，4）神经科学，和5）药理学。该计划的目标包括收购 基本的研究技能，掌握相关文献，理解负责任的行为， 研究，包括IRB/IACUC批准，能够以手稿形式总结研究结果， 赠款申请，并在公共场合，如杂志俱乐部和国家科学 会议.受训人员的进展情况由一个专门针对研究员的审查委员会定期监测 （第一年每季度与导师和研究员开会，此后每半年开会一次），并总结调查结果 向负责接受/雇用研究员的部门培训补助金执行委员会报告， 随着他们的进步。此外，一个UW范围内的外部科学监督委员会每年举行会议， 就培训方案的各个方面向执行委员会提供咨询意见。该计划的总体意图是 培养下一代围手术期医生科学家和学者。 相关性（参见说明）： 在手术和危重病期间，患者可重复地经历人类极限的压力。 生理学;这是一个独特的时期，人体组织样本也可以在道德上获得。 针对围手术期生理学的机械基础科学、转化和临床研究 提供了广泛相关的重要见解，这一事实最近得到了许多人的赞赏。 医学专业。随着人口老龄化，培养有能力解决 在这个重要的医学竞技场中，科学问题应该关注手术、创伤和 重症监护病人更安全。

The objective of this proposal is to provide in-depth research training in cutting edge (andemerging) areas of biomedical science related to anesthesiology and perioperative medicine, including critical care. The University of Washington (UW) Department of Anesthesiology has a long history of academic excellence and clinical innovation. This new program application aims to reinstate one of the longest running training programs in anesthesiology (35 year history). After a decade of space constraints, UW is rebuilding academic anesthesiology in significant ways, complete with research space commitments (total 24,000 square feet) and resources required to add 5-6 well funded mid- senior level physician-scientist and research scientist faculty. This proposal is designed to capitalize on these new departmental initiativesand, importantly, the existing outstanding research environment at UW in order to train the next generation of anesthesiology physician scientists. Trainees will be sought from a national pool of candidates. The structure of this program involves 2-3 years of research training closely supervised by NIH-funded UW faculty mentors on projects ranging from laboratory-based science to more translational and clinical projects; 3-4 new fellows will be enrolled each year who have completed anesthesiology residencies and relevant clinical subspecialty training (so fellows will be 5-6 years post-MD). Five major research areas relevant to perioperative medicine are emphasized. These include (alphabetically): 1) cardiovascular-pulmonary biology & regenerative medicine, 2) clinical outcomes research & epidemiology, 3) genome sciences & bioinformatics, 4) neurosciences, and 5) pharmacology. Goals of the program include acquisition of fundamental research skills, mastery of the relevant literature, understanding responsible conduct of research including IRB/IACUC approvals, ability to summarize research findings in manuscript form and grant applications, and presenting findings in public settings such as journal clubs and national scientific meetings. Trainee progress is monitored regularly by an individualized fellow-specific review committee (meeting with mentor and fellow quarterly in year 1, semi-annually thereafter) with summary findings reported to the departmental training grant executive committee responsible for accepting/hiring fellows and following their progress. In addition, a UW-wide external scientific oversight board meets yearly to offer advice to the executive committee on all aspects of the training program. The overall intent of the program is to develop the next generation of perioperative physician scientists and academicians. RELEVANCE (Seeinstructions): During surgery and critical illness, patients reproducibly experience stress to the limits of human physiology; this is a unique period where human tissue samples can be obtained ethically as well. Mechanistic basic science, translational, and clinical studies targeting perioperative physiology provide important insights broadly relevant across medicine, a fact recently appreciated by many medical specialties. With the aging population, developing physician scientists capable of tackling scientific questions in this important arena of medicine should make care of surgery, trauma, and intensive care patients safer.