Training in functional lipidomics in cardiovascular and respiratory diseases

描述（由申请人提供）：在此提议一个培训项目-脂质信号和功能脂质组学在心血管和呼吸疾病(LCRD) -为医学博士/博士研究生和博士后在弗吉尼亚联邦大学（VCU）医学院。LCRD培训计划是VCU长期创新心血管研究的产物，结合了我们在脂质代谢，信号传导和功能脂质组学方面的优势。在心脏、呼吸和心血管疾病的脂质信号和功能领域需要新的科学家，因为未来要成功地预防和治疗这些日益重要的人类疾病，将需要对所涉及的分子和细胞机制有深入的了解，并使用分子生物学、基因组和生物信息学技术，以及脂质组学/代谢组学的新技术。该计划的目标是为从事心脏、肺和血液疾病生物医学研究的独立研究者提供卓越的跨学科培训。这个跨部门培训项目由高素质的研究顾问单独指导，包括几位医学博士和医学博士/博士导师，他们是杰出的榜样，总体上由一个项目指导委员会指导，该委员会有两名成员，他们长期经营着非常成功的医学博士/博士项目。因此，康文署受训者将受益于更广泛的导师网络，包括个别受训者咨询委员会和康文署指导委员会的成员。培训包括严格的实验室研究、研讨会、高级课程、双周LCRD研讨会和年度LCRD研究静修。一个主要的优势是来自五个系的22名资金充足的项目教师的研究项目的质量，他们在与该项目主题重点相关的许多领域进行了富有成效、充满活力和合作的研究工作。学员受益于积极的教师参与，工作交流的经验，以及优秀的核心设施，包括最先进的脂质组学/代谢组学，所有这些都为培养下一代心血管和肺部研究者提供了极好的环境，他们将做出基本的生物医学发现并将其转化为更好的患者治疗结果。

DESCRIPTION (provided by applicant): Proposed herein is a training program - Lipid Signaling and Functional Lipidomics in Cardiovascular and Respiratory Diseases (LCRD) - for MD/PhD students and postdoctoral fellows at Virginia Commonwealth University (VCU) School of Medicine. The LCRD training program is an outgrowth of VCU's long history of innovative cardiovascular research combined with our strength in lipid metabolism, signaling, and functional lipidomics. New scientists are needed in the area of lipid signaling and functions in heart, respiratory, and cardiovascular disorders because future success in prevention and treatment of these increasingly important human diseases will require sophisticated understanding of the molecular and cellular mechanisms involved and the use of molecular biology, genomic and bioinformatics technology, as well as the new technology of lipidomics/metabolomics. The goal of the program is to provide exceptional interdisciplinary training in preparation for careers as independent investigators dedicated to biomedical research in heart, lung, and blood disorders. This interdepartmental training program is directed individually by highly qualified research advisors, including several MD and MD/PhD mentors who serve as outstanding role models, and overall by a program steering committee, which has two members who ran highly successful longstanding MD/PhD programs. Hence, LCRD trainees will benefit from an extended network of mentors, including members of their individual trainee advisory committees and the LCRD Steering Committee. Training includes rigorous laboratory research, seminars, advanced courses, biweekly LCRD Colloquium, and annual LCRD Research Retreat. A major strength is the quality of the research programs of the 22 well-funded program faculty members from five departments who have productive, energetic, and collaborative research efforts in many areas of relevant to thematic focus of this program. Trainees benefit from vigorous faculty involvement, experiences in communication of their work, and excellent core facilities, including state of the art lipidomics/metabolomics, all of which provide a superb environment for training the next generations of cardiovascular and pulmonary investigators who will make basic biomedical discoveries and translate them into better patient outcomes.