Training in functional lipidomics in cardiovascular and respiratory diseases

描述(由申请者提供)：建议在此为弗吉尼亚联邦大学(VCU)医学院的医学博士/博士研究生和博士后提供一项培训计划--心血管和呼吸系统疾病(LCRD)中的脂质信号和功能脂质组学。LCRD培训计划是VCU在创新心血管研究方面的长期历史与我们在脂质代谢、信号传递和功能脂质组学方面的优势相结合的产物。在心脏、呼吸系统和心血管疾病的脂质信号和功能领域需要新的科学家，因为未来在预防和治疗这些日益重要的人类疾病方面的成功将需要对所涉及的分子和细胞机制的深入了解，并使用分子生物学、基因组和生物信息学技术以及脂质组学/代谢组学新技术。该计划的目标是提供特殊的跨学科培训，为作为致力于心、肺和血液疾病生物医学研究的独立调查人员的职业生涯做准备。这一跨部门培训计划由高素质的研究顾问单独指导，其中包括几位作为杰出榜样的MD和MD/博士导师，总体上由一个计划指导委员会指导，该委员会有两名成员，他们成功地实施了长期的MD/博士计划。因此，LCRD学员将受益于扩大的导师网络，包括其个别学员咨询委员会和LCRD指导委员会的成员。培训包括严格的实验室研究、研讨会、高级课程、两周一次的LCRD座谈会和一年一度的LCRD研究务虚会。一个主要的优势是来自五个系的22名资金充足的项目教职员工的研究项目的质量，他们在与该项目的主题重点相关的许多领域做出了富有成效、充满活力和协作的研究努力。受训者受益于教师的积极参与、他们工作的沟通经验以及优秀的核心设施，包括最先进的脂质组学/代谢组学，所有这些都为培训下一代心血管和肺部研究人员提供了一个极好的环境，他们将做出基本的生物医学发现，并将其转化为更好的患者结果。

DESCRIPTION (provided by applicant): Proposed herein is a training program - Lipid Signaling and Functional Lipidomics in Cardiovascular and Respiratory Diseases (LCRD) - for MD/PhD students and postdoctoral fellows at Virginia Commonwealth University (VCU) School of Medicine. The LCRD training program is an outgrowth of VCU's long history of innovative cardiovascular research combined with our strength in lipid metabolism, signaling, and functional lipidomics. New scientists are needed in the area of lipid signaling and functions in heart, respiratory, and cardiovascular disorders because future success in prevention and treatment of these increasingly important human diseases will require sophisticated understanding of the molecular and cellular mechanisms involved and the use of molecular biology, genomic and bioinformatics technology, as well as the new technology of lipidomics/metabolomics. The goal of the program is to provide exceptional interdisciplinary training in preparation for careers as independent investigators dedicated to biomedical research in heart, lung, and blood disorders. This interdepartmental training program is directed individually by highly qualified research advisors, including several MD and MD/PhD mentors who serve as outstanding role models, and overall by a program steering committee, which has two members who ran highly successful longstanding MD/PhD programs. Hence, LCRD trainees will benefit from an extended network of mentors, including members of their individual trainee advisory committees and the LCRD Steering Committee. Training includes rigorous laboratory research, seminars, advanced courses, biweekly LCRD Colloquium, and annual LCRD Research Retreat. A major strength is the quality of the research programs of the 22 well-funded program faculty members from five departments who have productive, energetic, and collaborative research efforts in many areas of relevant to thematic focus of this program. Trainees benefit from vigorous faculty involvement, experiences in communication of their work, and excellent core facilities, including state of the art lipidomics/metabolomics, all of which provide a superb environment for training the next generations of cardiovascular and pulmonary investigators who will make basic biomedical discoveries and translate them into better patient outcomes.