COBRE Transitional Center in Neuroscience

COBRE 神经科学过渡中心

• 批准号: 7938335
• 负责人: GEORGE A SPIROU
• 金额: $ 109.88万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7938335
• 关键词: Applications Grants; Award; Centers of Research Excellence; Collaborations; Consultations; Core Facility; Drug Addiction; Electrons; Ensure; Faculty; Genomics; Grant; Image; Internships; Laboratories; Lasers; Light; Mentors; Microscopic; Neurodegenerative Disorders; Neurosciences; Nuclear Magnetic Resonance; Occupational activity of managing finances; Pathology; Phase; Pilot Projects; Research; Research Infrastructure; Research Project Grants; Science; Sensory Disorders; Stroke; Students; Technology; Technology Assessment; Training; Transgenic Animals; Translational Research; West Virginia; design; forging; health disparity; meetings; member; programs; public health relevance; tissue processing

DESCRIPTION (provided by applicant): This project is designed to meet the directives of the CoBRE phase III Transitional Award and will (1) further develop collaborative science and enhance training capabilities for faculty, postdoctoral and graduate trainees and undergraduate students and (2) support modern core facilities and continuously evolve them to provide modern technologies for collaborative research. We will continue existing, effective programs in our Center for Neuroscience for faculty mentoring, support for grant application and management, collaboration and interaction among all CN members, and a summer undergraduate research internship. We will support an institutional core facility director with broad responsibility for core facility oversight, financial management, efficiency and accessibility and advanced technology assessment. Five institutional cores will be supported, which have received support through earlier phases of the CoBRE grant: Transgenic Animal; Genomics; Advanced Imaging; Light and Electron Microscopic Imaging; Tissue Processing and Analysis. Each core is staffed with expert directors and three cores operate with doctorate level laboratory managers, ensuring high levels of expertise for experimental consultations with core users. The Advanced Imaging and Light and Electron Microscopic Imaging cores operate as technology discovery cores through collaborative involvement of laser, magnetic resonance and nuclear physicists who conduct research and assist with core management. Several core facilities are unique in our state, and support basic and translational research. PUBLIC HEALTH RELEVANCE (provided by applicant): Strong core facility infrastructure will provide direct support for a broad range of basic and translational research projects. These research topics include stroke and drug addiction, which are health disparities in West Virginia, and other pathologies such as congenital sensory disorders and neurodegenerative disease. Pilot projects are designed to forge new types of scientific collaborations to study these topics.

描述（由申请人提供）：该项目旨在满足 CoBRE 第三阶段过渡奖的指示，并将 (1) 进一步发展协作科学并增强教师、博士后和研究生以及本科生的培训能力；(2) 支持现代化核心设施并不断发展它们，为协作研究提供现代技术。我们将继续神经科学中心现有的有效项目，为教师提供指导、资助申请和管理支持、所有 CN 成员之间的协作和互动，以及暑期本科生研究实习。我们将支持机构核心设施主任，广泛负责核心设施监督、财务管理、效率和可及性以及先进技术评估。将支持五个机构核心，这些核心机构已在 CoBRE 赠款的早期阶段获得支持：转基因动物；基因组学；高级成像；光学和电子显微成像；组织处理和分析。每个核心均配备专家主任，三个核心由博士级实验室管理人员操作，确保与核心用户的实验咨询具有高水平的专业知识。先进成像以及光和电子显微成像核心作为技术发现核心，通过激光、磁共振和核物理学家的协作参与进行研究并协助核心管理。一些核心设施在我们州是独一无二的，支持基础研究和转化研究。 公共卫生相关性（由申请人提供）：强大的核心设施基础设施将为广泛的基础和转化研究项目提供直接支持。这些研究主题包括中风和毒瘾（西弗吉尼亚州的健康差异）以及其他疾病，例如先天性感觉障碍和神经退行性疾病。试点项目旨在建立新型科学合作来研究这些主题。