COBRE Transitional Center in Neuroscience

项目描述（由申请人提供）：本项目旨在满足CoBRE第三阶段过渡奖的指导，将(1)进一步发展合作科学，提高对教师、博士后和研究生学员以及本科生的培训能力；(2)支持现代核心设施，并不断发展它们，为合作研究提供现代技术。我们将继续我们神经科学中心现有的、有效的项目，包括教师指导、资助申请和管理支持、所有CN成员之间的协作和互动，以及本科生暑期研究实习。我们将支持设立机构核心设施主任，广泛负责核心设施监督、财务管理、效率和可及性以及先进技术评估。将支持五个机构核心，它们已通过CoBRE拨款的早期阶段获得支持：转基因动物；基因组学;先进的成像;光学和电子显微成像；组织处理与分析。每个核心都配备专家主任，三个核心配备博士级实验室管理人员，确保向核心用户提供高水平的实验咨询专业知识。先进成像、光和电子显微成像核心通过激光、磁共振和核物理学家的合作参与，作为技术发现核心，他们进行研究并协助核心管理。一些核心设施在我们州是独一无二的，并支持基础和转化研究。

DESCRIPTION (provided by applicant): This project is designed to meet the directives of the CoBRE phase III Transitional Award and will (1) further develop collaborative science and enhance training capabilities for faculty, postdoctoral and graduate trainees and undergraduate students and (2) support modern core facilities and continuously evolve them to provide modern technologies for collaborative research. We will continue existing, effective programs in our Center for Neuroscience for faculty mentoring, support for grant application and management, collaboration and interaction among all CN members, and a summer undergraduate research internship. We will support an institutional core facility director with broad responsibility for core facility oversight, financial management, efficiency and accessibility and advanced technology assessment. Five institutional cores will be supported, which have received support through earlier phases of the CoBRE grant: Transgenic Animal; Genomics; Advanced Imaging; Light and Electron Microscopic Imaging; Tissue Processing and Analysis. Each core is staffed with expert directors and three cores operate with doctorate level laboratory managers, ensuring high levels of expertise for experimental consultations with core users. The Advanced Imaging and Light and Electron Microscopic Imaging cores operate as technology discovery cores through collaborative involvement of laser, magnetic resonance and nuclear physicists who conduct research and assist with core management. Several core facilities are unique in our state, and support basic and translational research. PUBLIC HEALTH RELEVANCE (provided by applicant): Strong core facility infrastructure will provide direct support for a broad range of basic and translational research projects. These research topics include stroke and drug addiction, which are health disparities in West Virginia, and other pathologies such as congenital sensory disorders and neurodegenerative disease. Pilot projects are designed to forge new types of scientific collaborations to study these topics.