COBRE Transitional Center in Neuroscience

描述(申请人提供)：该项目旨在满足Cobre第三阶段过渡奖的指示，并将(1)进一步发展协作科学，并增强对教师、博士后、研究生学员和本科生的培训能力，(2)支持现代核心设施并不断发展它们，为协作研究提供现代技术。我们将继续在我们的神经科学中心继续现有的、有效的项目，用于教师指导、对拨款申请和管理的支持、所有CN成员之间的合作和互动，以及夏季本科生研究实习。我们将支持设立一名机构核心设施主任，广泛负责核心设施监督、财务管理、效率和可获得性以及先进技术评估。五个机构核心将得到支持，它们通过科布雷赠款的早期阶段得到了支持：转基因动物、基因组学、先进成像、光学和电子显微镜成像、组织处理和分析。每个核心都配备了专家主任，三个核心与博士级别的实验室经理一起运作，确保与核心用户进行实验咨询时具有高水平的专业知识。先进成像和光学和电子显微成像核心通过激光、磁共振和核物理学家的合作参与，作为技术发现核心运作，这些物理学家进行研究并协助核心管理。几个核心设施在我们州是独一无二的，支持基础研究和翻译研究。 公共卫生相关性(由申请者提供)：强大的核心设施基础设施将为广泛的基础和转化性研究项目提供直接支持。这些研究主题包括中风和药物成瘾，这是西弗吉尼亚州的健康差距，以及其他病理学，如先天性感觉障碍和神经退行性疾病。试点项目旨在形成研究这些主题的新型科学合作。

DESCRIPTION (provided by applicant): This project is designed to meet the directives of the CoBRE phase III Transitional Award and will (1) further develop collaborative science and enhance training capabilities for faculty, postdoctoral and graduate trainees and undergraduate students and (2) support modern core facilities and continuously evolve them to provide modern technologies for collaborative research. We will continue existing, effective programs in our Center for Neuroscience for faculty mentoring, support for grant application and management, collaboration and interaction among all CN members, and a summer undergraduate research internship. We will support an institutional core facility director with broad responsibility for core facility oversight, financial management, efficiency and accessibility and advanced technology assessment. Five institutional cores will be supported, which have received support through earlier phases of the CoBRE grant: Transgenic Animal; Genomics; Advanced Imaging; Light and Electron Microscopic Imaging; Tissue Processing and Analysis. Each core is staffed with expert directors and three cores operate with doctorate level laboratory managers, ensuring high levels of expertise for experimental consultations with core users. The Advanced Imaging and Light and Electron Microscopic Imaging cores operate as technology discovery cores through collaborative involvement of laser, magnetic resonance and nuclear physicists who conduct research and assist with core management. Several core facilities are unique in our state, and support basic and translational research. PUBLIC HEALTH RELEVANCE (provided by applicant): Strong core facility infrastructure will provide direct support for a broad range of basic and translational research projects. These research topics include stroke and drug addiction, which are health disparities in West Virginia, and other pathologies such as congenital sensory disorders and neurodegenerative disease. Pilot projects are designed to forge new types of scientific collaborations to study these topics.