COBRE Transitional Center in Neuroscience

COBRE 神经科学过渡中心

• 批准号: 8691912
• 负责人: GEORGE A SPIROU
• 金额: $ 106.45万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2016-09-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8691912
• 关键词: Academic Medical Centers; Address; Applications Grants; Area; Award; Basic Science; Biological; Biological Process; Brain imaging; Cataloging; Catalogs; Centers of Research Excellence; Collaborations; Consultations; Core Facility; Data Collection; Disease; Drug Addiction; Educational workshop; Electrons; Ensure; Environment; Faculty; Floor; Fostering; Freezing; Funding; Future; Genomics; Goals; Grant; Growth; Health Sciences; Housing; Image; Imagery; Individual; Institution; Internships; Investigation; Investments; Journals; Laboratories; Lasers; Light; Marshal; Mental disorders; Mentors; Microscopic; Microscopy; Mission; Modeling; National Center for Research Resources; Nature; Neurodegenerative Disorders; Neurosciences; Neurosciences Research; Nuclear Magnetic Resonance; Occupational activity of managing finances; Online Systems; Optics; Participant; Pathology; Phase; Pilot Projects; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Sampling; Science; Scientist; Sensory Disorders; Series; Stroke; Structure; System; Techniques; Technology; Technology Assessment; Training; Transgenic Animals; Translational Research; United States National Institutes of Health; Universities; Visit; West Virginia; Work; base; cognitive neuroscience; design; forging; health disparity; improved; meetings; member; multidisciplinary; peer; programs; sensory neuroscience; success; tissue processing; tool; undergraduate research; undergraduate student

This project is designed to meet the directives of the CoBRE phase III Transitional Award and will (1) further develop collaborative science and enhance training capabilities for faculty, postdoctoral and graduate trainees and undergraduate students and (2) support modern core facilities and continuously evolve them to provide modern technologies for collaborative research. We will continue existing, effective programs in our Center for Neuroscience for faculty mentoring, support for grant application and management, collaboration and interaction among all CN members, and a summer undergraduate research internship. We will support an institutional core facility director with broad responsibility for core facility oversight, financial management, efficiency and accessibility and advanced technology assessment. Five institutional cores will be supported, which have received support through earlier phases of the CoBRE grant: Transgenic Animal; Genomics; Advanced Imaging; Light and Electron Microscopic Imaging; Tissue Processing and Analysis. Each core is staffed with expert directors and three cores operate with doctorate level laboratory managers, ensuring high levels of expertise for experimental consultations with core users. The Advanced Imaging and Light and Electron Microscopic Imaging cores operate as technology discovery cores through collaborative involvement of laser, magnetic resonance and nuclear physicists who conduct research and assist with core management. Several core facilities are unique in our state, and support basic and translational research.

该项目旨在满足Cobre第三阶段过渡奖的指示，并将(1)进一步发展协作科学，增强对教职员工、博士后、研究生实习生和本科生的培训能力，(2)支持现代核心设施，并不断发展它们，为协作研究提供现代技术。我们将继续在我们的神经科学中心继续现有的、有效的项目，用于教师指导、对拨款申请和管理的支持、所有CN成员之间的合作和互动，以及夏季本科生研究实习。我们将支持设立一名机构核心设施主任，广泛负责核心设施监督、财务管理、效率和可获得性以及先进技术评估。五个机构核心将得到支持，它们通过科布雷赠款的早期阶段得到了支持：转基因动物、基因组学、先进成像、光学和电子显微镜成像、组织处理和分析。每个核心都配备了专家主任，三个核心与博士级别的实验室经理一起运作，确保与核心用户进行实验咨询时具有高水平的专业知识。先进成像和光学和电子显微成像核心通过激光、磁共振和核物理学家的合作参与，作为技术发现核心运作，这些物理学家进行研究并协助核心管理。几个核心设施在我们州是独一无二的，支持基础研究和翻译研究。

项目成果

Quantitative comparisons on hand motor functional areas determined by resting state and task BOLD fMRI and anatomical MRI for pre-surgical planning of patients with brain tumors.

• DOI: 10.1016/j.nicl.2016.03.003
• 发表时间: 2016
• 期刊: NeuroImage. Clinical
• 作者: Hou BL;Bhatia S;Carpenter JS
• 通讯作者: Carpenter JS

Chinese-English bilinguals show linguistic-perceptual links in the brain associating short spoken phrases with corresponding real-world natural action sounds by semantic category.

• DOI: 10.1080/23273798.2021.1883073
• 发表时间: 2021
• 期刊: Language, cognition and neuroscience
• 作者: Valencia GN;Khoo S;Wong T;Ta J;Hou B;Barsalou LW;Hazen K;Lin HH;Wang S;Brefczynski-Lewis JA;Frum CA;Lewis JW
• 通讯作者: Lewis JW

Functional and resting-state characterizations of a periventricular heterotopic nodule associated with epileptogenic activity.

• DOI: 10.3171/2019.11.focus19765
• 发表时间: 2020-02-01
• 期刊: Neurosurgical focus
• 影响因子: 4.1
• 作者: Nolan RL;Brandmeir N;Tucker ES;Magruder JL;Lee MR;Chen G;Lewis JW
• 通讯作者: Lewis JW

Concept of an upright wearable positron emission tomography imager in humans.

• DOI: 10.1002/brb3.530
• 发表时间: 2016-09
• 期刊: BRAIN AND BEHAVIOR
• 影响因子: 3.1
• 作者: Bauer, Christopher E.;Brefczynski-Lewis, Julie;Marano, Gary;Mandich, Mary-Beth;Stolin, Alexander;Martone, Peter;Lewis, James W.;Jaliparthi, Gangadhar;Raylman, Raymond R.;Majewski, Stan
• 通讯作者: Majewski, Stan

Divergent Human Cortical Regions for Processing Distinct Acoustic-Semantic Categories of Natural Sounds: Animal Action Sounds vs. Vocalizations.

用于处理自然声音的不同声学语义类别的不同人类皮质区域：动物动作声音与发声。

• DOI: 10.3389/fnins.2016.00579
• 发表时间: 2016
• 期刊: Frontiers in neuroscience
• 影响因子: 4.3
• 作者: Webster,PaulaJ;Skipper-Kallal,LauraM;Frum,ChrisA;Still,HayleyN;Ward,BDouglas;Lewis,JamesW
• 通讯作者: Lewis,JamesW