COBRE Transitional Center in Neuroscience

COBRE 神经科学过渡中心

• 批准号: 8691912
• 负责人: GEORGE A SPIROU
• 金额: $ 106.45万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2016-09-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8691912
• 关键词: Academic Medical Centers; Address; Applications Grants; Area; Award; Basic Science; Biological; Biological Process; Brain imaging; Cataloging; Catalogs; Centers of Research Excellence; Collaborations; Consultations; Core Facility; Data Collection; Disease; Drug Addiction; Educational workshop; Electrons; Ensure; Environment; Faculty; Floor; Fostering; Freezing; Funding; Future; Genomics; Goals; Grant; Growth; Health Sciences; Housing; Image; Imagery; Individual; Institution; Internships; Investigation; Investments; Journals; Laboratories; Lasers; Light; Marshal; Mental disorders; Mentors; Microscopic; Microscopy; Mission; Modeling; National Center for Research Resources; Nature; Neurodegenerative Disorders; Neurosciences; Neurosciences Research; Nuclear Magnetic Resonance; Occupational activity of managing finances; Online Systems; Optics; Participant; Pathology; Phase; Pilot Projects; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Sampling; Science; Scientist; Sensory Disorders; Series; Stroke; Structure; System; Techniques; Technology; Technology Assessment; Training; Transgenic Animals; Translational Research; United States National Institutes of Health; Universities; Visit; West Virginia; Work; base; cognitive neuroscience; design; forging; health disparity; improved; meetings; member; multidisciplinary; peer; programs; sensory neuroscience; success; tissue processing; tool; undergraduate research; undergraduate student

This project is designed to meet the directives of the CoBRE phase III Transitional Award and will (1) further develop collaborative science and enhance training capabilities for faculty, postdoctoral and graduate trainees and undergraduate students and (2) support modern core facilities and continuously evolve them to provide modern technologies for collaborative research. We will continue existing, effective programs in our Center for Neuroscience for faculty mentoring, support for grant application and management, collaboration and interaction among all CN members, and a summer undergraduate research internship. We will support an institutional core facility director with broad responsibility for core facility oversight, financial management, efficiency and accessibility and advanced technology assessment. Five institutional cores will be supported, which have received support through earlier phases of the CoBRE grant: Transgenic Animal; Genomics; Advanced Imaging; Light and Electron Microscopic Imaging; Tissue Processing and Analysis. Each core is staffed with expert directors and three cores operate with doctorate level laboratory managers, ensuring high levels of expertise for experimental consultations with core users. The Advanced Imaging and Light and Electron Microscopic Imaging cores operate as technology discovery cores through collaborative involvement of laser, magnetic resonance and nuclear physicists who conduct research and assist with core management. Several core facilities are unique in our state, and support basic and translational research.

该项目旨在满足CoBRE第三阶段过渡奖的指示，并将(1)进一步发展合作科学，提高对教师，博士后和研究生学员以及本科生的培训能力；(2)支持现代核心设施，并不断发展它们，为合作研究提供现代技术。我们将继续我们神经科学中心现有的、有效的项目，包括教师指导、资助申请和管理支持、所有CN成员之间的协作和互动，以及本科生暑期研究实习。我们将支持设立机构核心设施主任，广泛负责核心设施监督、财务管理、效率和可及性以及先进技术评估。将支持五个机构核心，它们已通过CoBRE拨款的早期阶段获得支持：转基因动物；基因组学;先进的成像;光学和电子显微成像；组织处理与分析。每个核心都配备专家主任，三个核心配备博士级实验室管理人员，确保向核心用户提供高水平的实验咨询专业知识。先进成像、光和电子显微成像核心通过激光、磁共振和核物理学家的合作参与，作为技术发现核心，他们进行研究并协助核心管理。一些核心设施在我们州是独一无二的，并支持基础和转化研究。

项目成果

Quantitative comparisons on hand motor functional areas determined by resting state and task BOLD fMRI and anatomical MRI for pre-surgical planning of patients with brain tumors.

• DOI: 10.1016/j.nicl.2016.03.003
• 发表时间: 2016
• 期刊: NeuroImage. Clinical
• 作者: Hou BL;Bhatia S;Carpenter JS
• 通讯作者: Carpenter JS

Chinese-English bilinguals show linguistic-perceptual links in the brain associating short spoken phrases with corresponding real-world natural action sounds by semantic category.

• DOI: 10.1080/23273798.2021.1883073
• 发表时间: 2021
• 期刊: Language, cognition and neuroscience
• 作者: Valencia GN;Khoo S;Wong T;Ta J;Hou B;Barsalou LW;Hazen K;Lin HH;Wang S;Brefczynski-Lewis JA;Frum CA;Lewis JW
• 通讯作者: Lewis JW

Functional and resting-state characterizations of a periventricular heterotopic nodule associated with epileptogenic activity.

• DOI: 10.3171/2019.11.focus19765
• 发表时间: 2020-02-01
• 期刊: Neurosurgical focus
• 影响因子: 4.1
• 作者: Nolan RL;Brandmeir N;Tucker ES;Magruder JL;Lee MR;Chen G;Lewis JW
• 通讯作者: Lewis JW

Concept of an upright wearable positron emission tomography imager in humans.

• DOI: 10.1002/brb3.530
• 发表时间: 2016-09
• 期刊: BRAIN AND BEHAVIOR
• 影响因子: 3.1
• 作者: Bauer, Christopher E.;Brefczynski-Lewis, Julie;Marano, Gary;Mandich, Mary-Beth;Stolin, Alexander;Martone, Peter;Lewis, James W.;Jaliparthi, Gangadhar;Raylman, Raymond R.;Majewski, Stan
• 通讯作者: Majewski, Stan

Divergent Human Cortical Regions for Processing Distinct Acoustic-Semantic Categories of Natural Sounds: Animal Action Sounds vs. Vocalizations.

用于处理自然声音的不同声学语义类别的不同人类皮质区域：动物动作声音与发声。

• DOI: 10.3389/fnins.2016.00579
• 发表时间: 2016
• 期刊: Frontiers in neuroscience
• 影响因子: 4.3
• 作者: Webster,PaulaJ;Skipper-Kallal,LauraM;Frum,ChrisA;Still,HayleyN;Ward,BDouglas;Lewis,JamesW
• 通讯作者: Lewis,JamesW