Molecular mechanisms of joint degeneration in osteoarthritis

骨关节炎关节退变的分子机制

• 批准号: nhmrc : 1063133
• 负责人: Prof Christopher Little
• 金额: $ 47.89万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-mechanisms-joint-degeneration-osteoarthritis/455043
• 关键词: Molecular; mechanisms; joint; degeneration; osteoarthritis

Arthritis is a major clinical and socio-economic problem. Arthritis involves the destruction of cartilage in joints. However, the mechanisms of initiation and progression of cartilage destruction remain poorly understood. Our studies will for explore the role of a new regulator of gene expression, microRNA, in the initation and progression of osteoarthritis. This will provide important new information on disease mechanisms for the development of diagnostic biomarkers and therapies

关节炎是一个重大的临床和社会经济问题。关节炎涉及关节软骨的破坏。然而，软骨破坏的发生和发展的机制仍不清楚。我们的研究将探索一种新的基因表达调节因子--microRNA在骨关节炎的发生和发展中的作用。这将为诊断生物标记物和治疗方法的开发提供关于疾病机制的重要新信息。