Bone-specific sclerostin and SIBLING proteins in osteoarthritis: novel contributions to cartilage and bone pathology

骨关节炎中的骨特异性硬化蛋白和 SIBLING 蛋白：对软骨和骨病理学的新贡献

• 批准号: nhmrc : 607399
• 负责人: Prof Christopher Little
• 金额: $ 29.41万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/bone-specific-sclerostin-bone-pathology/96558
• 关键词: Bone; specific; sclerostin; SIBLING; proteins

Arthritis is a major clinical problem and involves the destruction of cartilage in joints. However, the mechanisms of how this cartilage destruction is initiated and progresses remain poorly understood. We recently discovered that that three proteins that play a role in bone are also produced in cartilage and are increased in cartilage during osteoarthritis. We will determine the role of each of these in the disease mechanism to provide new therapeutic and biomarker targets.

关节炎是一个主要的临床问题，涉及关节软骨的破坏。然而，这种软骨破坏是如何开始和进展的机制仍然知之甚少。我们最近发现，在骨中起作用的三种蛋白质也在软骨中产生，并且在骨关节炎期间在软骨中增加。我们将确定每一种在疾病机制中的作用，以提供新的治疗和生物标志物靶点。