Synovial macrophages and T-cells are therapeutic targets in osteoarthritis

滑膜巨噬细胞和 T 细胞是骨关节炎的治疗靶点

• 批准号: nhmrc : 1045890
• 负责人: Prof Christopher Little
• 金额: $ 43.93万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/synovial-macrophages-t-targets-osteoarthritis/111799
• 关键词: Synovial; macrophages; cells; therapeutic; targets

Osteoarthritis (OA) is the most widespread musculoskeletal disease in Australia and there are currently no therapies that halt disease progression. Specific inflammatory events play a pivotal role in initiating and driving OA progression. In this study we will define the specific inflammatory cells involved in OA, how and why they change with time, and which can be targeted to stop disease onset and development. This will provide the platform for initiating human clinical trials.

骨关节炎 (OA) 是澳大利亚最常见的肌肉骨骼疾病，目前尚无任何疗法可以阻止疾病进展。特定的炎症事件在引发和驱动 OA 进展中发挥着关键作用。在这项研究中，我们将定义与 OA 相关的特定炎症细胞，它们如何以及为何随时间变化，以及哪些细胞可以靶向阻止疾病的发作和发展。这将为启动人体临床试验提供平台。