Sclerostin is a key regulator of Wnt signalling in bone and cartilage pathology in osteoarthritis

硬化蛋白是骨关节炎骨和软骨病理学中 Wnt 信号传导的关键调节因子

• 批准号: nhmrc : 1026511
• 负责人: Prof Christopher Little
• 金额: $ 39.4万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/sclerostin-key-regulator-pathology-osteoarthritis/110502
• 关键词: Sclerostin; key; regulator; Wnt; signalling

Osteoarthritis (OA) is the most widespread bone and joint problem in Australia with has enormous social and economic consequences. We have identified Sclerostin (SOST) as a key regulator of the signalling pathway that drives the increase in production of bone and the erosion of cartilage in joints that are the hallmark of OA. The aims of the present project are to determine the effect altering SOST activity on the initiation and progression of OA.

骨关节炎（OA）是澳大利亚最普遍的骨和关节问题，具有巨大的社会和经济后果。我们已经确定硬化蛋白（SOST）作为信号通路的关键调节因子，该信号通路驱动骨生成增加和关节软骨侵蚀，这是OA的标志。本项目的目的是确定改变SOST活性对OA发生和进展的影响。