Molecular mechanisms mediating experience-dependent cellular plasticity and cognitive deficits in Huntingtons disease

介导亨廷顿病经验依赖性细胞可塑性和认知缺陷的分子机制

• 批准号: nhmrc : 509031
• 负责人: Prof Anthony Hannan
• 金额: $ 36.7万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-mechanisms-mediating-huntingtons-disease/83078
• 关键词: Molecular; mechanisms; mediating; experience; dependent

We will use a genetic mouse model of Huntington's disease (HD), to understand how cognitive disorders (dementia) are caused, focusing on cells and molecules within the brain. We will investigate how the HD gene mutation disrupts communication between brain cells (neurons), as well as disrupting production of new cells (via adult neural stem cells). The results of this project will not only have implications for treating HD but also for other diseases involving dementia, such as Alzheimer's.

我们将使用亨廷顿氏病（HD）的遗传小鼠模型，以了解认知障碍（痴呆症）是如何引起的，重点是大脑内的细胞和分子。我们将研究HD基因突变如何破坏脑细胞（神经元）之间的通信，以及破坏新细胞（通过成体神经干细胞）的产生。该项目的结果不仅对治疗HD有意义，而且对其他涉及痴呆症的疾病，如阿尔茨海默氏症也有意义。