Studying the two hit hypothesis of psychiatric illness: role of brain-derived neurotrophic factor (BDNF)

研究精神疾病的两次打击假说：脑源性神经营养因子（BDNF）的作用

• 批准号: nhmrc : 566879
• 负责人: Prof Anthony Hannan
• 金额: $ 31.31万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/studying-hit-hypothesis-factor-bdnf/82289
• 关键词: Studying; two; hit; hypothesis; psychiatric

Early environmental factors may play an important role in the development of psychiatric illnesses, such as schizophrenia and depression. We will study an animal model which combines early developmental stress followed by treatment with a stress hormone or chronic cannabis use in adolescence. We will assess behavioural changes and the role of a growth factor in the brain, BDNF. This wil lead to a better understanding of the role of neurodevelopmental stress in psychiatric disease.

早期环境因素可能在精神疾病的发展中起重要作用，如精神分裂症和抑郁症。我们将研究一种动物模型，该模型将早期发育压力与青春期压力激素或慢性大麻使用相结合。我们将评估行为变化和大脑中生长因子BDNF的作用。这将导致更好地理解神经发育应激在精神疾病中的作用。