Gene-environment interactions, experience-dependent plasticity and pathogenic mechanisms in mouse models of cognitive and affective disorders. Mental and physical activity as modulators of brain and behaviour in healthy and diseased states.

认知和情感障碍小鼠模型中的基因-环境相互作用、经验依赖性可塑性和致病机制。

• 批准号: nhmrc : 1004475
• 负责人: Prof Anthony Hannan
• 金额: $ 16.72万
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/gene-environment-interactions-diseased-states/109037
• 关键词: Gene; environment; interactions; experience; dependent

Our aim is to understand how genes and environment combine to affect susceptibility to various brain disorders. We are using specific models involving human gene mutations associated with diseases, and manipulating environmental factors such as mental and physical activity. We are focused on neurological and psychiatric disorders, including Huntington’s disease, depression and schizophrenia. These efforts to understand brain diseases will facilitate development of therapeutic approaches.

我们的目标是了解基因和环境是如何结合在一起影响各种大脑疾病的易感性的。我们正在使用与疾病相关的人类基因突变的特定模型，并操纵精神和体力活动等环境因素。我们专注于神经和精神障碍，包括亨廷顿氏症、抑郁症和精神分裂症。这些了解脑部疾病的努力将促进治疗方法的发展。