Gene-environment interactions, experience-dependent plasticity and pathogenic mechanisms in mouse models of cognitive and affective disorders. Mental and physical activity as modulators of brain and behaviour in healthy and diseased states.

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Our aim is to understand how genes and environment combine to affect susceptibility to various brain disorders. We are using specific models involving human gene mutations associated with diseases, and manipulating environmental factors such as mental and physical activity. We are focused on neurological and psychiatric disorders, including Huntington’s disease, depression and schizophrenia. These efforts to understand brain diseases will facilitate development of therapeutic approaches.