Experience-dependent cellular plasticity and cognitive deficits in mouse models of schizophrenia

精神分裂症小鼠模型中经验依赖性细胞可塑性和认知缺陷

• 批准号: nhmrc : 1034785
• 负责人: Prof Anthony Hannan
• 金额: $ 29.63万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/experience-dependent-cellular-models-schizophrenia/110935
• 关键词: Experience; dependent; cellular; plasticity; cognitive

Schizophrenia is a brain disorder involving psychiatric symptoms which include abnormalities of cognitive processes. We are using mouse models to understand the cause of cognitive deficits, at the level of molecules and cells. One discovery we have made is that the generation of new neurons, from adult neural stem cells, are abnormal in a specific brain region of these mice. This research will provide new information regarding the cause of cognitive deficits, and will have implications for the development of new treatments.

精神分裂症是一种涉及精神症状的脑部疾病，包括认知过程异常。我们正在用老鼠模型来了解认知缺陷的原因，在分子和细胞的水平上。我们的一项发现是，在这些小鼠的特定大脑区域中，来自成年神经干细胞的新神经元的产生是不正常的。这项研究将提供有关认知缺陷原因的新信息，并将对开发新的治疗方法产生影响。