Experience-dependent cellular plasticity and cognitive deficits in mouse models of schizophrenia

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Schizophrenia is a brain disorder involving psychiatric symptoms which include abnormalities of cognitive processes. We are using mouse models to understand the cause of cognitive deficits, at the level of molecules and cells. One discovery we have made is that the generation of new neurons, from adult neural stem cells, are abnormal in a specific brain region of these mice. This research will provide new information regarding the cause of cognitive deficits, and will have implications for the development of new treatments.