Prospective Study of Traumatic Stress in Police Officers
Prospective Study of Traumatic Stress in Police Officers
批准号:
8209165
负责人:
Charles R. Marmar
金额:
$74.36万
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-09-30 至 2013-12-31
关键词:
AcademyAcousticsAdolescentAgeAlcohol abuseAngerApplications GrantsAreaBehavioralBehavioral GeneticsBiologicalBiological MarkersBiologyBritishBudgetsCalendarCampingCatechol O-MethyltransferaseCatecholaminesCharacteristicsChildhoodClinicalCognitionCognitive TherapyCohort StudiesComplexCross-Sectional StudiesDNADataDiabetes MellitusDiagnosticDiseaseDissociationDistressDreamsDysthymic DisorderEarthquakesEconomic InflationEmergency SituationEndocrineEnrollmentEventExpenditureExposure toFamilyFamily history ofFemaleFrightFunctional Magnetic Resonance ImagingFundingGalvanic Skin ResponseGenderGender RoleGeneral PopulationGenesGenetic PolymorphismGenotypeGoalsHeart DiseasesHeart RateHourHuman ResourcesHydrocortisoneIncomeIncubatedIndividualInterviewInvestigationLaboratoriesLaw EnforcementLeftLifeLiteratureLow incomeMalignant NeoplasmsMarital StatusMeasuresMediatingMedicalMemoryMental DepressionMethyltransferase GeneMississippiModelingMood DisordersNeurotic DisordersNew YorkOccupationsParticipantPatient Self-ReportPerformancePhasePhobic anxiety disorderPhysical FitnessPolicePolice officerPositioning AttributePost-Traumatic Stress DisordersPrincipal InvestigatorProceduresProcessProspective StudiesPsychological TestsPsychopathologyPsychophysiologyPsychosocial Assessment and CarePublishingReactionRecording of previous eventsRecruitment ActivityRelative (related person)ReportingResearchResearch DesignRespondentRiskRisk MarkerRoleSan FranciscoServicesShockSleepSocial supportStagingStressSurveysSymptomsTestingThyroid DiseasesTimeTrainingTraining ProgramsTraumaVariantWorkWorkplaceactigraphybasecareerchronic paincohortcostdepressive symptomsemotion regulationemotional distressfollow-uphigh riskinjuredmeetingsnovel markerpediatric traumapeerphysical conditioningprogramsprospectivepsychosocialresearch studyresilienceresponsesecondary outcomeserotonin transportershift worksimulationsleep onsetstressortraitvigilancewillingness
中文摘要
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英文摘要
This is a competitive renewal application for grant RO1 MH 056350-o6 ?Prospective Study of Posttraumatic
Stress in Police Officers?. The goal of this research is to advance understanding of risk and resilience factors
for posttraumatic stress disorder. We have enrolled 400 police academy recruits assessed on a
comprehensive set of biological and psychosocial characteristics during training. Recruits were reassessed
during the first two years of police service on duty-related critical incident and routine work environment
stressors, stressors and support outside of police service, and PTSD symptoms. We are requesting five
years of support to follow our cohort through years three through seven of police service, a time of high risk
for cumulative exposure and for leaving police service.
The primary aims for the renewal are to determine prospectively if the following predictors explain PTSD
symptoms across the first seven years of police service: (1) Psychosocial characteristics including IQ, trait
dissociation, prior trauma, family history, neuroticism, worldview and trait anger assessed during academy
training; (2) Biomarkers including awakening cortisol, acoustic startle, endocrine and psychophysiological
responses to critical incident simulation and actigraphy assessed during academy training; (3) Exposure to
life threatening critical incidents and peritraumatic responses assessed during police service; (4)Routine
work stress, negative life events outside police service and social support assessed during police service; (5)
Genetic polymorphisms; (6) Greater work hours and shift work during years 3 and 5 of police service and
determine if this relationship is explained by wake after sleep onset and sleep duration as measured by
actigraphy; and (7 ) Determine genetic and behavioral predictors of depression symptoms across the first
seven years of police service
We are well positioned to conduct the proposed research which will be the largest and most comprehensive
prospective study of risk and resilience factors for posttraumatic stress in law enforcement. We have recruited and
comprehensively assessed 400 academy recruits. We have successfully managed laboratories in New York and
San Francisco. The academy recruits have generously agreed to participate in intensive testing including critical
incident simulation and shock enhanced startle testing. We have retained nearly 84% and 82% of those due for
one year and two year assessments, respectively. We have less than 3% missing data across all procedures and
time points. Rates of critical incident exposure are high in the first year with 95.4 % reporting critical incidents,
nearly half involving personal life threat. Results to date strongly support the aims for the renewal. After one year of
police service the strongest predictors of PTSD symptoms are lower I.Q. and higher levels of trait dissociation
assessed during academy training, greater personal life threat and peritraumatic dissociation at the time of incident
exposure, and greater routine work environment stress and negative life events during the first year of service.
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DOI:
10.1016/j.brat.2006.01.008
发表时间:
2007-01-01
期刊:
BEHAVIOUR RESEARCH AND THERAPY
影响因子:
4.1
作者:
[Fikretoglu, Deniz, Brunet, Alain, Marmar, Charles R.]
通讯作者:
Marmar, Charles R.
DOI:
10.1016/j.jpsychires.2009.05.011
发表时间:
2010-01
期刊:
Journal of psychiatric research
影响因子:
4.8
作者:
[Inslicht SS, McCaslin SE, Metzler TJ, Henn-Haase C, Hart SL, Maguen S, Neylan TC, Marmar CR]
通讯作者:
Marmar CR
DOI:
10.1097/nmd.0b013e31818ec95d
发表时间:
2008-12
期刊:
The Journal of nervous and mental disease
影响因子:
--
作者:
[McCaslin SE, Inslicht SS, Metzler TJ, Henn-Haase C, Maguen S, Neylan TC, Choucroun G, Marmar CR]
通讯作者:
Marmar CR
DOI:
10.1016/j.janxdis.2009.02.015
发表时间:
2009-08
期刊:
Journal of anxiety disorders
影响因子:
10.3
作者:
[Lilly MM, Pole N, Best SR, Metzler T, Marmar CR]
通讯作者:
Marmar CR
Pharmacologic alternatives to antidepressants in posttraumatic stress disorder: a systematic review.
DOI:
10.1016/j.pnpbp.2008.12.004
发表时间:
2009-03-17
期刊:
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
影响因子:
5.6
作者:
[Berger, William, Mendlowicz, Mauro V., Marques-Portella, Carla, Kinrys, Gustavo, Fontenelle, Leonardo F., Marmar, Charles R., Figueira, Ivan]
通讯作者:
Figueira, Ivan
共 10 条
Leveraging systems pharmacology to advance precision medicine for Gabapentin treatment of AUD
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批准号:10887866
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项目类别:
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资助金额:$16.95万
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财政年份:2023
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负责人:Charles R. Marmar
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依托单位:
Leveraging systems pharmacology to advance precision medicine for Gabapentin treatment of AUD
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批准号:10629306
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资助金额:$75.08万
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财政年份:2022
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依托单位:
Leveraging biomarkers for personalized treatment of alcohol use disorder comorbid with PTSD
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批准号:10237280
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项目类别:
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资助金额:$120.28万
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财政年份:2018
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依托单位:
Leveraging biomarkers for personalized treatment of alcohol use disorder comorbid with PTSD
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批准号:10237281
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项目类别:
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资助金额:$7.53万
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财政年份:2018
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负责人:Charles R. Marmar
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依托单位:
Leveraging biomarkers for personalized treatment of alcohol use disorder comorbid with PTSD
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批准号:10473674
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项目类别:
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资助金额:$120.49万
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财政年份:2018
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负责人:Charles R. Marmar
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依托单位:
Leveraging biomarkers for personalized treatment of alcohol use disorder comorbid with PTSD
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批准号:10473675
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项目类别:
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资助金额:$9.96万
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财政年份:2018
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负责人:Charles R. Marmar
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依托单位:
Cannabidiol as a treatment for alcohol use disorder comorbid with posttraumatic stress disorder
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批准号:9436640
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项目类别:
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资助金额:$24.37万
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财政年份:2017
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负责人:Charles R. Marmar
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依托单位:
CBT for PTSD in Disaster Relief Workers
-
批准号:6541484
-
项目类别:
-
资助金额:$22.24万
-
财政年份:2002
-
负责人:Charles R. Marmar
-
依托单位:
POSTTRAUMATIC STRESS IN POLICE OFFICERS
-
批准号:6433890
-
项目类别:
-
资助金额:$20.11万
-
财政年份:1997
-
负责人:Charles R. Marmar
-
依托单位:
POSTTRAUMATIC STRESS IN POLICE OFFICERS
-
批准号:2407399
-
项目类别:
-
资助金额:$60.08万
-
财政年份:1997
-
负责人:Charles R. Marmar
-
依托单位:
Prospective Study of Traumatic Stress in Police Officers
-
批准号:7755356
-
项目类别:
-
资助金额:$65.59万
-
财政年份:1997
-
负责人:Charles R. Marmar
-
依托单位:
Prospective Study of Traumatic Stress in Police Officers
-
批准号:6998963
-
项目类别:
-
资助金额:$107.44万
-
财政年份:1997
-
负责人:Charles R. Marmar
-
依托单位:
POSTTRAUMATIC STRESS IN POLICE OFFICERS
-
批准号:2890873
-
项目类别:
-
资助金额:$73.24万
-
财政年份:1997
-
负责人:Charles R. Marmar
-
依托单位:
Prospective Study of Traumatic Stress in Police Officers
-
批准号:6621174
-
项目类别:
-
资助金额:$78.97万
-
财政年份:1997
-
负责人:Charles R. Marmar
-
依托单位:
Prospective Study of Traumatic Stress in Police Officers
-
批准号:7483908
-
项目类别:
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资助金额:$16.5万
-
财政年份:1997
-
负责人:Charles R. Marmar
-
依托单位:
Prospective Study of Traumatic Stress in Police Officers
-
批准号:8131086
-
项目类别:
-
资助金额:$76.44万
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财政年份:1997
-
负责人:Charles R. Marmar
-
依托单位:
Prospective Study of Traumatic Stress in Police Officers
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批准号:6430757
-
项目类别:
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资助金额:$72.62万
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财政年份:1997
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负责人:Charles R. Marmar
-
依托单位:
Prospective Study of Traumatic Stress in Police Officers
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批准号:7380283
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项目类别:
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资助金额:$72.22万
-
财政年份:1997
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负责人:Charles R. Marmar
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依托单位:
Prospective Study of Traumatic Stress in Police Officers
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批准号:6680919
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项目类别:
-
资助金额:$86.62万
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财政年份:1997
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负责人:Charles R. Marmar
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依托单位:
POSTTRAUMATIC STRESS IN POLICE OFFICERS
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批准号:2675571
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项目类别:
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资助金额:$76.09万
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财政年份:1997
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负责人:Charles R. Marmar
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依托单位:
海外基金