Prospective Study of Traumatic Stress in Police Officers

警务人员创伤应激的前瞻性研究

• 批准号: 8209165
• 负责人: Charles R. Marmar
• 金额: $ 74.36万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2013-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8209165
• 关键词: Academy; Acoustics; Adolescent; Age; Alcohol abuse; Anger; Applications Grants; Area; Behavioral; Behavioral Genetics; Biological; Biological Markers; Biology; British; Budgets; Calendar; Camping; Catechol O-Methyltransferase; Catecholamines; Characteristics; Childhood; Clinical; Cognition; Cognitive Therapy; Cohort Studies; Complex; Cross-Sectional Studies; DNA; Data; Diabetes Mellitus; Diagnostic; Disease; Dissociation; Distress; Dreams; Dysthymic Disorder; Earthquakes; Economic Inflation; Emergency Situation; Endocrine; Enrollment; Event; Expenditure; Exposure to; Family; Family history of; Female; Fright; Functional Magnetic Resonance Imaging; Funding; Galvanic Skin Response; Gender; Gender Role; General Population; Genes; Genetic Polymorphism; Genotype; Goals; Heart Diseases; Heart Rate; Hour; Human Resources; Hydrocortisone; Income; Incubated; Individual; Interview; Investigation; Laboratories; Law Enforcement; Left; Life; Literature; Low income; Malignant Neoplasms; Marital Status; Measures; Mediating; Medical; Memory; Mental Depression; Methyltransferase Gene; Mississippi; Modeling; Mood Disorders; Neurotic Disorders; New York; Occupations; Participant; Patient Self-Report; Performance; Phase; Phobic anxiety disorder; Physical Fitness; Police; Police officer; Positioning Attribute; Post-Traumatic Stress Disorders; Principal Investigator; Procedures; Process; Prospective Studies; Psychological Tests; Psychopathology; Psychophysiology; Psychosocial Assessment and Care; Publishing; Reaction; Recording of previous events; Recruitment Activity; Relative (related person); Reporting; Research; Research Design; Respondent; Risk; Risk Marker; Role; San Francisco; Services; Shock; Sleep; Social support; Staging; Stress; Surveys; Symptoms; Testing; Thyroid Diseases; Time; Training; Training Programs; Trauma; Variant; Work; Workplace; actigraphy; base; career; chronic pain; cohort; cost; depressive symptoms; emotion regulation; emotional distress; follow-up; high risk; injured; meetings; novel marker; pediatric trauma; peer; physical conditioning; programs; prospective; psychosocial; research study; resilience; response; secondary outcome; serotonin transporter; shift work; simulation; sleep onset; stressor; trait; vigilance; willingness

This is a competitive renewal application for grant RO1 MH 056350-o6 ?Prospective Study of Posttraumatic Stress in Police Officers?. The goal of this research is to advance understanding of risk and resilience factors for posttraumatic stress disorder. We have enrolled 400 police academy recruits assessed on a comprehensive set of biological and psychosocial characteristics during training. Recruits were reassessed during the first two years of police service on duty-related critical incident and routine work environment stressors, stressors and support outside of police service, and PTSD symptoms. We are requesting five years of support to follow our cohort through years three through seven of police service, a time of high risk for cumulative exposure and for leaving police service. The primary aims for the renewal are to determine prospectively if the following predictors explain PTSD symptoms across the first seven years of police service: (1) Psychosocial characteristics including IQ, trait dissociation, prior trauma, family history, neuroticism, worldview and trait anger assessed during academy training; (2) Biomarkers including awakening cortisol, acoustic startle, endocrine and psychophysiological responses to critical incident simulation and actigraphy assessed during academy training; (3) Exposure to life threatening critical incidents and peritraumatic responses assessed during police service; (4)Routine work stress, negative life events outside police service and social support assessed during police service; (5) Genetic polymorphisms; (6) Greater work hours and shift work during years 3 and 5 of police service and determine if this relationship is explained by wake after sleep onset and sleep duration as measured by actigraphy; and (7 ) Determine genetic and behavioral predictors of depression symptoms across the first seven years of police service We are well positioned to conduct the proposed research which will be the largest and most comprehensive prospective study of risk and resilience factors for posttraumatic stress in law enforcement. We have recruited and comprehensively assessed 400 academy recruits. We have successfully managed laboratories in New York and San Francisco. The academy recruits have generously agreed to participate in intensive testing including critical incident simulation and shock enhanced startle testing. We have retained nearly 84% and 82% of those due for one year and two year assessments, respectively. We have less than 3% missing data across all procedures and time points. Rates of critical incident exposure are high in the first year with 95.4 % reporting critical incidents, nearly half involving personal life threat. Results to date strongly support the aims for the renewal. After one year of police service the strongest predictors of PTSD symptoms are lower I.Q. and higher levels of trait dissociation assessed during academy training, greater personal life threat and peritraumatic dissociation at the time of incident exposure, and greater routine work environment stress and negative life events during the first year of service.

这是授予RO1 MH 056350-O6的竞争更新申请？ 警察的压力？这项研究的目的是提高对风险和韧性因素的理解 用于创伤后应激障碍。我们已经招募了400名警察学院的新兵 培训期间的一系列生物和社会心理特征集。新兵被重新评估 在警察服务的头两年中 警察服务外的压力源，压力源和支持以及PTSD症状。我们要求五个 多年的支持，以跟随我们的队列，直到三年级到七年的警察服务，这是一个高风险的时期 累积暴露和离开警察服务。 更新的主要目的是前瞻性确定以下预测因子是否解释PTSD 警察服务的前七年中的症状：（1）社会心理特征，包括智商，特质 分离，先前的创伤，家族史，神经质，世界观和特质愤怒在学院期间评估 训练; （2）生物标志物，包括觉醒皮质醇，声学惊吓，内分泌和心理生理学 对学院培训期间评估的关键事件模拟​​和精力法的响应； （3）接触 威胁生命的关键事件和警察服务期间评估的腹膜腹膜反应； （4）例程 工作压力，警察服务以外的负面生活事件以及在警察服务期间评估的社会支持； （5） 遗传多态性； （6）在警察服务的第3年和第5年中，更大的工作时间和轮班工作以及 确定睡眠发作后的唤醒和睡眠持续时间是否通过 动作； （7）确定第一个抑郁症状的遗传和行为预测因子 七年警察服务 我们有能力进行拟议的研究，该研究将是最大，最全面的研究 前瞻性研究对执法后创伤后压力的风险和弹性因素。我们已经招募了 全面评估了400名学院新兵。我们在纽约成功管理实验室， 旧金山。学院的新兵慷慨地同意参加密集测试，包括关键 事件模拟和冲击增强了惊吓测试。我们保留了将近84％和82％ 一年和两年评估。在所有程序中，我们的数据少于3％，并且 时间点。第一年的关键事件暴露发生率很高，有95.4％的报告关键事件， 将近一半涉及个人生活威胁。迄今为止的结果强烈支持续签的目标。一年后 警察服务最强的PTSD症状预测因子是智商较低。和更高水平的性状分离 在学院培训期间评估，事件发生时更大的个人生命威胁和周围的分离 在服务的第一年，曝光以及更大的常规工作环境压力和负面的生活事件。

项目成果

Peritraumatic fear, helplessness and horror and peritraumatic dissociation: Do physical and cognitive symptoms of panic mediate the relationship between the two?

• DOI: 10.1016/j.brat.2006.01.008
• 发表时间: 2007-01-01
• 期刊: BEHAVIOUR RESEARCH AND THERAPY
• 影响因子: 4.1
• 作者: Fikretoglu, Deniz;Brunet, Alain;Marmar, Charles R.
• 通讯作者: Marmar, Charles R.

Family psychiatric history, peritraumatic reactivity, and posttraumatic stress symptoms: a prospective study of police.

• DOI: 10.1016/j.jpsychires.2009.05.011
• 发表时间: 2010-01
• 期刊: Journal of psychiatric research
• 影响因子: 4.8
• 作者: Inslicht SS;McCaslin SE;Metzler TJ;Henn-Haase C;Hart SL;Maguen S;Neylan TC;Marmar CR
• 通讯作者: Marmar CR

Gender and PTSD: What can we learn from female police officers?

• DOI: 10.1016/j.janxdis.2009.02.015
• 发表时间: 2009-08
• 期刊: Journal of anxiety disorders
• 影响因子: 10.3
• 作者: Lilly MM;Pole N;Best SR;Metzler T;Marmar CR
• 通讯作者: Marmar CR

Trait dissociation predicts posttraumatic stress disorder symptoms in a prospective study of urban police officers.

• DOI: 10.1097/nmd.0b013e31818ec95d
• 发表时间: 2008-12
• 期刊: The Journal of nervous and mental disease
• 作者: McCaslin SE;Inslicht SS;Metzler TJ;Henn-Haase C;Maguen S;Neylan TC;Choucroun G;Marmar CR
• 通讯作者: Marmar CR

Pharmacologic alternatives to antidepressants in posttraumatic stress disorder: a systematic review.

• DOI: 10.1016/j.pnpbp.2008.12.004
• 发表时间: 2009-03-17
• 期刊: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
• 影响因子: 5.6
• 作者: Berger, William;Mendlowicz, Mauro V.;Marques-Portella, Carla;Kinrys, Gustavo;Fontenelle, Leonardo F.;Marmar, Charles R.;Figueira, Ivan
• 通讯作者: Figueira, Ivan