Molecular mechanisms of renal fibrosis
Molecular mechanisms of renal fibrosis
批准号:
nhmrc : 628634
负责人:
A/Pr Chrishan Samuel
金额:
$25.0万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2012-12-31
中文摘要
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英文摘要
Fibrosis is a key cause of renal pathology-dysfunction. Relaxin is an endogenous reno-protective factor, and thus has enormous therapeutic potential. However, despite compelling pre-clinical evidence of its efficacy, little is known about relaxin's mechanism of action. These studies will lead to a much better understanding of its signal transduction properties that will allow us to maximise its anti-fibrotic potential; identify new targets for intervention; and design better clinical trials.
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会议论文
Pharmacological inhibition of IRAP as a novel antifibrotic strategy
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批准号:nhmrc : GNT1146049
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项目类别:Project Grants
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资助金额:$103.64万
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财政年份:2018
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负责人:A/Pr Chrishan Samuel
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依托单位:
Pharmacological inhibition of IRAP as a novel antifibrotic strategy
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批准号:nhmrc : 1146049
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项目类别:Project Grants
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资助金额:$70.07万
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财政年份:2018
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负责人:A/Pr Chrishan Samuel
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依托单位:
Unraveling fibrosis by pharmacological targeting of the G protein-coupled receptor, RXFP1
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批准号:nhmrc : GNT1122170
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项目类别:Project Grants
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资助金额:$79.86万
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财政年份:2017
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负责人:A/Pr Chrishan Samuel
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依托单位:
Unraveling fibrosis by pharmacological targeting of the G protein-coupled receptor, RXFP1
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批准号:nhmrc : 1122170
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项目类别:Project Grants
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资助金额:$54.45万
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财政年份:2017
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负责人:A/Pr Chrishan Samuel
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依托单位:
Understanding the cardio-protective actions of the AT2R in females: Shifting gears between AT1 and AT2 receptor balance of function with relaxin.
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批准号:nhmrc : GNT1101552
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项目类别:Project Grants
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资助金额:$104.93万
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财政年份:2016
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负责人:A/Pr Chrishan Samuel
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依托单位:
Understanding the cardio-protective actions of the AT2R in females: Shifting gears between AT1 and AT2 receptor balance of function with relaxin.
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批准号:nhmrc : 1101552
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项目类别:Project Grants
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资助金额:$72.15万
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财政年份:2016
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负责人:A/Pr Chrishan Samuel
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依托单位:
Tubulointerstitial Epigenetics- The Underlying Basis of Progressive Fibrosis in Kidney Disease
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批准号:nhmrc : 1078694
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项目类别:Project Grants
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资助金额:$25.27万
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财政年份:2015
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负责人:A/Pr Chrishan Samuel
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依托单位:
Tubulointerstitial Epigenetics- The Underlying Basis of Progressive Fibrosis in Kidney Disease
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批准号:nhmrc : GNT1078694
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项目类别:Project Grants
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资助金额:$36.71万
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财政年份:2015
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负责人:A/Pr Chrishan Samuel
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依托单位:
Developing Relaxin Peptides as Novel Therapies for Fibrosis
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批准号:nhmrc : 1041766
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项目类别:Research Fellowships
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资助金额:$50.1万
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财政年份:2013
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负责人:A/Pr Chrishan Samuel
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依托单位:
Developing Novel Therapies for Fibrosis
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批准号:nhmrc : GNT1041766
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项目类别:Research Fellowships
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资助金额:$59.08万
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财政年份:2013
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负责人:A/Pr Chrishan Samuel
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依托单位:
Relaxin therapy reverses large artery remodelling and stiffening in aged and hypertensive models
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批准号:nhmrc : 1004235
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项目类别:Project Grants
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资助金额:$29.67万
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财政年份:2011
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负责人:A/Pr Chrishan Samuel
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依托单位:
Novel Candidate Genes, Lung Function and Allergic Airways Disease
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批准号:nhmrc : 546428
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项目类别:NHMRC Project Grants
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资助金额:$38.8万
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财政年份:2009
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负责人:A/Pr Chrishan Samuel
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依托单位:
Investigating the anti-fibrotic properties of relaxin in the normal and diseased heart
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批准号:nhmrc : 454636
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项目类别:Career Development Fellowships
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资助金额:$31.95万
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财政年份:2007
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负责人:A/Pr Chrishan Samuel
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依托单位:
国内基金
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