Tubulointerstitial Epigenetics- The Underlying Basis of Progressive Fibrosis in Kidney Disease

肾小管间质表观遗传学——肾脏疾病进行性纤维化的根本基础

• 批准号: nhmrc : 1078694
• 负责人: A/Pr Chrishan Samuel
• 金额: $ 25.27万
• 依托单位: Melbourne Vic.
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/tubulointerstitial-epigenetics-underlying-kidney-disease/518600
• 关键词: Tubulointerstitial; Epigenetics; Underlying; Basis; Progressive

Although the kidney has capacity to repair after mild injuries, ongoing or severe injury results in scarring (so-called fibrosis) and a progressive loss of kidney function. Understanding the mechanisms that regulate the transition from repair to fibrosis is important, because once fibrosis is initiated it can be extremely difficult to switch off or reverse.

虽然肾脏在轻度损伤后有修复能力，但持续或严重的损伤会导致瘢痕形成（所谓的纤维化）和肾功能的进行性丧失。了解调节从修复到纤维化转变的机制是很重要的，因为一旦纤维化开始，就很难关闭或逆转。